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Virchows Archiv A

, Volume 390, Issue 2, pp 193–204 | Cite as

Renin localization in segmental renal hypoplasia

Immunohistochemical demonstration in two cases
  • D. Amat
  • J. P. Camilleri
  • Vuong Ngoc Phat
  • J. Bariety
  • P. Corvol
  • J. Menard
Original Articles

Summary

The distribuation of renin in two cases of segmental renal hypoplasia was investigated by immunofluorescence and the peroxidase anti-peroxidase (PAP) method using an anti-human renin antiserum. Renin-containing cells were found only in hypoplasic segments in the vicinity of altered glomeruli and small arteries. Well-preserved renal cortex and areas of chronic atrophic pyelonephritis failed to show any demonstrable site of renin production.

Whatever is the mechanism of the disease, the characterization of large numbers of renin-containing cells in the affected kidney support a role for the renin-angiotensin system stimulation in this form of hypertension.

Key words

Renin Kidney Segmental renal hypoplasia Hypertension Immunofluorescence Peroxidase anti-peroxidase (PAP) 

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Copyright information

© Springer-Verlag 1981

Authors and Affiliations

  • D. Amat
    • 1
  • J. P. Camilleri
    • 1
  • Vuong Ngoc Phat
    • 1
  • J. Bariety
    • 1
  • P. Corvol
    • 2
  • J. Menard
    • 2
  1. 1.Laboratoire Central d'Anatomie PathologiqueINSERM U 28 and CNRS ERA 48, Hôpital BroussaisParis cédex 14France
  2. 2.INSERM U 36ParisFrance

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