Renin localization in segmental renal hypoplasia
- 27 Downloads
The distribuation of renin in two cases of segmental renal hypoplasia was investigated by immunofluorescence and the peroxidase anti-peroxidase (PAP) method using an anti-human renin antiserum. Renin-containing cells were found only in hypoplasic segments in the vicinity of altered glomeruli and small arteries. Well-preserved renal cortex and areas of chronic atrophic pyelonephritis failed to show any demonstrable site of renin production.
Whatever is the mechanism of the disease, the characterization of large numbers of renin-containing cells in the affected kidney support a role for the renin-angiotensin system stimulation in this form of hypertension.
Key wordsRenin Kidney Segmental renal hypoplasia Hypertension Immunofluorescence Peroxidase anti-peroxidase (PAP)
Unable to display preview. Download preview PDF.
- Ask Upmark E (1929) Über juvenile maligne Neproskle und ihr Verhöeltuis zu störingen in der Nierenentwickling. Acta Pathol Microbiol Scand. 7:383–442Google Scholar
- Barajas L, Marks LS, Trygstadt CW (1977) Unilateral renal hypoplasia with associated venous anomaly and hypertension. Virchows Arch A Path Anat and Histol 374:169–182Google Scholar
- Blaine EH, Davis JO (1971) Evidence for a renal vascular mechanism in renin release: new observations with graded stimulation by aortic constriction. Circ Res 28–29:118–126Google Scholar
- Camilleri JP, Vuong N Phat, Bariety J, Corvol P, Menard J (1980) Use of a specific antiserum for renin retention in human kidney. J Histochem Cytochem (in press)Google Scholar
- Galen FX, Devaux C, Guyenne TT, Menard J, Corvol P (1979a) Multiple forms of human renin: purification and characterisation. J Biol Clin 254:4848Google Scholar
- Godard C, Vallonton MB, Broyer M (1973) Plasma renin activity in segmental hypoplasia of the kidneys with hypertension. Nephron II:307–317Google Scholar
- Habib R (1979) Pathology of renal segmental corticopapillary scarring in children with hypertension: the concept of semtnal hypoplasia in reflux nephropathy. Hadson J, Kincaid Smith P (eds). Massen USA, New York, p 220–239Google Scholar
- Holland NH, Kotchen T, Chathena D (1975) Hypertension in children with chronic pyelonephritis. Kidney Int 8:243–251Google Scholar
- Kinlaid-Smith P (1975) Glomerular lesions in atrophic pyelonephritis and reflux nephropathy. Kidney Int 8:81–83Google Scholar
- Kissane JM (1974) Congenital malformation. In: Heptinstall (ed) Pathology of the kidney, 2nd edn. Little Borwn and Co, Boston, p 73–74Google Scholar
- Mozziconacci P, Attal C, Boisse J, Pham-Huu-Tring MT, Guy-Grand D, Durand C (1968) Hypoplasie segmentaire du rein avec hypertension artérielle. Ann Pediat 44:337–351Google Scholar
- Sternberger LA (1974) Immunocytochemistry. Prentice Hall Inc, Englewood CliffsGoogle Scholar