Abstract
Five calves were given live intranasal vaccine against bovid herpesvirus 1 (BHV1) two days after intranasal inoculation of bovine pestivirus (BVDV). Another 5 were vaccinated in the absence of BVDV. Control unvaccinated groups were also maintained. All calves were challenged with virulent BHV1. The unvaccinated calves developed signs of infectious bovine rhinotracheitis (IBR) and both vaccinated groups showed a similar degree of clinical protection from IBR. Those given BVDV before vaccination shed up to 140 times more BHV1 (P<0.01) in the nasal mucus following challenge than those which had received BHV1 vaccine alone. The epidemiological significance of this is discussed.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Edwards, S. and Roeder, P.L., 1983. Attempted reactivation of latent bovine herpesvirus 1 infection in calves by infection with ruminant pestiviruses. Veterinary Microbiology, 8: 563–569.
Frerichs, G.N., Woods, S.B., Lucas, M.H. and Sands, J.J., 1982. Safety and efficacy of live and inactivated infectious bovine rhinotracheitis vaccines. Veterinary Record, 111: 116–122.
Potgieter, L.N.D., McCracken, M.D., Hopkins, F.M. and Walker, R.D., 1984. Effect of bovine viral diarrhea virus infection on the distribution of infectious bovine rhinotracheitis virus in calves. American Journal of Veterinary Research, 45: 687–690.
Reggiardo, C. and Kaeberle, M.L., 1981. Detection of bacteremia in cattle inoculated with bovine viral diarrhea virus. American Journal of Veterinary Research, 42: 218–221.
Roth, J.A., Kaeberle, M.L. and Griffith, R.W., 1981. Effects of bovine viral diarrhea virus infection on bovine polymorphonuclear leukocyte function. American Journal of Veterinary Research, 42: 244–250.
Roth, J.A. and Kaeberle, M.L., 1983. Suppression of neutrophil and lymphocyte function induced by a vaccinal strain of bovine viral diarrhea virus with and without the administration of ACTH. American Journal of Veterinary Research, 44: 2366–2372.
Thomas, L.H., Stott, E.J., Collins, A.P., Jebbett, N.J. and Stark, A.J., 1977. Evaluation of respiratory disease in calves: comparison of disease response to different viruses. Research in Veterinary Science, 23: 157–164.
Yates, W.D.G., 1984. Interaction between viruses and bacteria in bovine respiratory disease. Canadian Veterinary Journal, 25: 37–41.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Edwards, S., Wood, L., Hewitt-Taylor, C. et al. Evidence for an immunocompromising effect of bovine pestivirus on bovid herpesvirus 1 vaccination. Vet Res Commun 10, 297–302 (1986). https://doi.org/10.1007/BF02213992
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02213992