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Digestive Diseases and Sciences

, Volume 41, Issue 4, pp 785–790 | Cite as

Capsaicin-sensitive sensory neurons are involved in bicarbonate secretion induced by lansoprazole, a proton pump inhibitor, in rats

  • Ikuko Inada
  • Hiroshi Satoh
Esophageal, Gastric, and Duodenal Disorders

Abstract

Lansoprazole, a proton pump inhibitor, exerts prominent antiulcer activityvia both antisecretory and mucosal protective actions. Although the antisecretory action has been explained by inactivation of (H+, K+)-ATPase in parietal cells, the mode of mucosal protective action remains to be elucidated. In the present study, the effect of lansoprazole on duodenal bicarbonate secretion was studied in anesthetized rats to clarify the mode of the mucosal protective action. Lansoprazole (0.1 mM) applied topically to the duodenum significantly (P<0.01) increased bicarbonate secretion by 0.36±0.11 μeq/15 min (21±5%) compared with the value in the vehicle control. Topical administration of capsaicin (10 mg/ml) in the duodenum and intravenous infusion of vasoactive intestinal peptide (10 μg/kg/hr) increased bicarbonate secretion. Five-minute perfusion of the duodenal loop with 100 mM HCl increased bicarbonate secretion. Administration of lansoprazole (0.3 and 1 mg/kg, intravenously) 60 min before luminal acidification enhanced the acid-induced bicarbonate secretion dose-dependently and significantly (P<0.01). In the capsaicin-pretreated rats, the effects of lansoprazole on basal and acid-induced bicarbonate secretion were significantly (P<0.05) decreased compared with that of control group. These results indicate that lansoprazole increases basal and acid-induced bicarbonate secretion in the duodenum in rats and that capsaicin-sensitive sensory neurons may be involved in the mode of action for these effects.

Key Words

bicarbonate secretion capsaicin-sensitive sensory neurons lansoprazole proton pump inhibitor vasoactive intestinal peptide 

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Copyright information

© Plenum Publishing Corporation 1996

Authors and Affiliations

  • Ikuko Inada
    • 1
  • Hiroshi Satoh
    • 1
  1. 1.Pharmaceutical Research Laboratories IIPharmaceutical Research Division, Takeda Chemical Industries, LtdYodogawa-ku, OskaJapan

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