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Journal of Assisted Reproduction and Genetics

, Volume 12, Issue 10, pp 715–719 | Cite as

Comparison between nafarelin acetate andd-Trp6-LHRH for temporary pituitary suppression in in vitro fertilization (IVF) patients: A prospective crossover study

  • Vasilios Tanos
  • Shevach Friedler
  • Asher Shushan
  • Nurith Strauss
  • Iftach Hetsroni
  • Aby Lewin
Physiology

Abstract

Purpose

Nafarelin acetate is a new gonadotropin releasing (GnRH) agonist analogue with unique potency, intranasal administration, and convenient storage. Hence, nafarelin was considered as an alternative for temporary pituitary suppression in patients undergoing ovulation induction in IVF. A crossover treatment in a prospective study was performed including 40 women with bilateral obstructed tubes and normal ovarian function, treated in 80 ovulation induction cycles using the long protocol. Twenty patients used nafarelin acetate 600 Μg/daily in their first cycle and receivedd-Trp6-LHRH, 0.5 mg/daily, in their following cycle. The other 20 women used decapeptyl in their first cycle and received nafarelin in the second.

Results

Estradiol suppression was achieved by bothd-Trp6-LHRH and nafarelin at equal time intervals. The average total number of ampoules (P=0.0005) and the length of administration of hMG required for ovarian stimulation (P=0.0002) and the time interval between GnRHa initiation to oocyte retrieval (P=0.04) was significantly lower in nafarelin cycles. The number and the distribution between large and small follicles as well as the average number of oocytes retrieved did not differ between the two GnRH analogues.

Conclusion

Our results demonstrate that nafarelin acetate is comparable tod-Trp6-LHRH for temporary pituitary suppression used for controlled ovarian stimulation in IVF patients. However, using nafarelin ovarian stimulation was achieved with fewer ampoules of hMG, administered for a shorter period of time, thus with a lesser cost.

Key words

nafarelin acetate gonadotropin releasing hormone analogues controlled ovarian stimulation in vitro fertilization pituitary suppression 

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Copyright information

© Plenum Publishing Corporation 1995

Authors and Affiliations

  • Vasilios Tanos
    • 1
  • Shevach Friedler
    • 1
  • Asher Shushan
    • 1
  • Nurith Strauss
    • 1
  • Iftach Hetsroni
    • 1
  • Aby Lewin
  1. 1.Department of Obstetrics and GynecologyHadassah University HospitalJerusalem

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