Fenfluramine treatment of twenty children with autism
The effects of fenfluramine were examined on 20 children with autism over a 48-week period utilizing a double-blind placebo-controlled crossover design. Blood and urine samples and psychological tests (Griffith's Developmental Scales and Real Life Rating Scale) were obtained at each crossover period. The only significant improvement was a decrease in abnormal motor behavior. We did not find any significant improvement in intellectual functioning or any correlation between good clinical response and low baseline serotonin levels or high baseline IQ. Serotonin decreased 53% after fenfluramine treatment and rebounded to a level 35% higher than baseline following a placebo period. Fenfluramine and the active metabolite norfenfluramine were determined in plasma samples.
KeywordsSerotonin Crossover Design Fenfluramine Psychological Test Serotonin Level
Unable to display preview. Download preview PDF.
- Alin-Åkerman, B., & Nordberg, L. (1980).Griffiths' utvecklingsskalor I och II. Stockholm: Psykologiförlaget AB.Google Scholar
- American Psychiatric Association. (1980).Diagnostic and statistical manual of mental disorders. (3rd ed.). Washington DC: Author.Google Scholar
- American Psychiatric Association. (1985).Draft DSM III-R in development (Work group to revise DSM-III). Washington, DC: Author.Google Scholar
- Campbell, D. B. (1971). Plasma concentrations of fenfluramine and its metabolite, norfenfluramine after single and repeated oral administration.British Journal of Pharmacology, 43, 465–466.Google Scholar
- Garattini, S., Buczko, W., Jori, A., & Samanin, R. (1975). The mechanism of action of fenfluramine.Postgraduate Medical Journal (Suppl. 1),51, 27–35.Google Scholar
- Goldstein, M., Mahanand, P., Lee, J., & Coleman, M. (1976). Dopamine-beta-hydroxylase and endogenous total 5-hydroxyindole levels in autistic patients and controls. In M. Coleman (Ed.),The autistic syndrome (pp. 57–63). Amsterdam: Elsevier/North Holland.Google Scholar
- Ho, H., Lockitch, G., Eaves, L., & Jacobson, B. (1986). Blood serotonim concentrations and fenfluramine therapy in autistic children.Pediatric Pharmacology and Therapeutics, 108, 465–469.Google Scholar
- Kohler, J. (1985). Is autism a biochemical abnormality?Communication, 19, 13.Google Scholar
- Ritvo, E. R., Freeman, B. J., Yuwiler, A., Geller, E., Schroth, P., Yokota, A. Mason-Brothers, A., August, G. J., Klykylo, W., Leventhal, B., Lewis, K., Piggott, L., Realmuto, G., Stubbs, G., & Umansky, R. (1986). Fenfluramine treatment of autism: UCLA-collaborative study of 81 patients at nine medical centers.Psychopharmacology Bulletin, 22, 133–140.PubMedGoogle Scholar
- Ritvo, E. R., Rabin, K., Yuwiler, A., Freeman, B. J., & Geller, E. (1980). Biochemical and hematologic studies of children with the syndrome of autism, childhood schizophrenia, and related developmental disabilities: A critical review. In M. Rutter & E. Schopler (Eds.), Autism: A reappraisal of concepts (pp. 163–183). New York: Plenum Press.Google Scholar
- Rutter, M. (1978). Diagnosis and definition. In M. Rutter, & E. Schopler (Eds.),Autism: A reappraisal of concepts and treatment (pp. 1–25). London: Plenum Press.Google Scholar
- Swedish Central Bureau of Statistics. (1982).Swedish socioeconomic classification. Stockholm: Statistics Sweden.Google Scholar