Journal of Assisted Reproduction and Genetics

, Volume 12, Issue 9, pp 632–638 | Cite as

Ultrastructure of endometrial epithelial cells in a three-dimensional cell culture system for human implantation studies

  • U. Bentin-Ley
  • S. Lindenberg
  • T. Horn
  • J. Falck Larsen



A three-dimensional cell culture system imitating normal uterine endometrium has previously been established. To what degree do cultured epithelial cells retain their morphological characteristics as compared to in vivomaterial obtained simultaneously from the same tissue donor.


We found a high degree of similarity between the in vivoand in vitrosituations. The present culture system furthermore imitates the day-to-day morphology of the cycle.


This indicates, that a correct timing of the biopsy tissue is important for future human implantation studies.

Key Words

cells cultured endometrium human in vitro ultrastructure, implantation 


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Copyright information

© Plenum Publishing Corporation 1995

Authors and Affiliations

  • U. Bentin-Ley
    • 1
  • S. Lindenberg
    • 1
    • 3
  • T. Horn
    • 2
  • J. Falck Larsen
    • 1
  1. 1.Department of Obstetrics-Gynecology, Herlev HospitalUniversity of CopenhagenHerlevDenmark
  2. 2.Department of Pathology, Herlev HospitalUniversity of CopenhagenHerlevDenmark
  3. 3.Ciconia Fertility ClinicFrederiksberg CDenmark

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