Journal of Autism and Developmental Disorders

, Volume 18, Issue 4, pp 553–559 | Cite as

Serotonin and measured intelligence

  • Edwin H. CookJr.
  • Bennett L. Leventhal
  • Daniel X. Freedman
Article

Abstract

Blood serotonin (5HT) has been shown to be elevated in 30% of autistic children and 50% of severely mentally retarded children. Ninety-eight normal adult subjects were studied to determined if there was an inverse relationship between whole blood 5HT in normal adults of average and above-average intelligence. There was a trend toward a negative correlation between whole blood 5HT and Vocabulary scores that would not account for hyperserotonemia in autistic or mentally retarded individuals. Female subjects had significantly greater whole blood 5HT than male subjects. There was no difference in whole blood 5HT collected before and after volume depletion of 450 ml, providing further evidence of the intraindividual stability of whole blood serotonin levels. There was no relationship between age and whole blood 5HT in a group of normal adult subjects.

Keywords

Serotonin Negative Correlation Inverse Relationship School Psychology Male Subject 

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References

  1. Anderson, G. M., Young, J. G., Cohen, D. J., Schlicht, K. R., & Patel, N. (1981). Liquidchromatographic determination of serotonin and tryptophan in whole blood and plasma.Clinical Chemistry 27, 775.Google Scholar
  2. Armstrong, M. D., McCall, R. B., & Stave, U. (1973). A study of plasma free amino acid levels. VIII. The relationship between plasma amino acid levels and IQ test peformance.Metabolism, 22, 1437–1441.Google Scholar
  3. Belendiuk, K., Belendiuk, G. W., & Freedman, D. X. (1980). Blood monoamine metabolism in Huntington's disease.Archives of General Psychiatry, 37, 325–332.Google Scholar
  4. Belendiuk, K., Belendiuk, G. W., & Freedman, D. X. (1981). Neurotransmitter abnormalities in patients with motor neuron disease.Archives of Neurology, 38, 415–417.Google Scholar
  5. Campbell, M., Freidman, E., De Vito, E., Greenspan, L., & Collins, P. J. (1974). Blood serotonin in psychotic and brain damaged children.Journal of Autism and Childhood Schizophrenia, 4, 33–41.Google Scholar
  6. Freedman, D. X., Belendiuk, K., Belendiuk, G. W., & Crayton, J. W. (1981). Blood tryptophan metabolism in chronic schizophrenics.Archives of General Psychiatry, 38, 655–659.Google Scholar
  7. Gonzales, G. F. (1980). Blood levels of 5-hydroxytryptamine in human beings under several physiological situations.Life Sciences, 27, 647–650.Google Scholar
  8. Guicheney, P., & Marcel, D. (1984). Decrease of platelet serotonin content in ovariectomized female rats.Endocrinology, 114, 2412–2414.Google Scholar
  9. Hanley, H. G., Stahl, S. M. & Freedman, D. X. (1977). Hyperserotonemia and amine metabolites in autistic and retarded children.Archives of General Psychiatry, 34, 521–531.Google Scholar
  10. Hoshino, Y., Ymamoto, T., Kaneko, M., Tachibana, R., Watanabe, M., Ono, Y., & Kumashiro, H. (1984). Blood serotonin and free tryptophan concentration in autistic children.Neuropsychobiology, 11, 22–27.Google Scholar
  11. Irwin, M., Belendiuk, K., McCloskey, K., & Freedman, D. X. (1981). Tryptophan metabolism in children with attentional deficit disorder.American Journal of Psychiatry, 138, 1082–1085.Google Scholar
  12. Kuperman, S., Beeghly, J., Burns, T., & Tsai, L. (1987). Association of serotonin concentration to behavior and IQ in autistic children.Journal of Autism and Developmental Disorders, 17, 133–140.Google Scholar
  13. McCoy, E. E., & Enns, L. (1978). Sodium transport, ouabain binding, and (Na+/K+)-ATPase activity in Down's syndrome platelets.Pediatric Research, 12, 685–689.Google Scholar
  14. McCoy, E. E., Segal, D. J., Bayer, S. M. & Strynadka, K. D. (1974). Decreased ATPase and increased sodium content of platelets in Down's syndrome-relation to decreased serotonin content.New England Journal of Medicine, 291, 950–953.Google Scholar
  15. Oikawa, K., Deonauth, J., & Breidbart, S. (1978). Mental retardation and elevated serotonin levels in adults.Life Sciences, 23, 45–48.Google Scholar
  16. Pare, C. M. B., Sandler, M., & Stacey, R. S. (1960). 5-Hydroxyndoles in mental deficiency.Journal of Neurology, Neurosurgery, and Psychiatry, 23, 341–346.Google Scholar
  17. Partington, M. W., Tu, J. B., & Wong, C. Y. (1973). Blood serotonin levels in severe mental retardation.Developmental Medicine and Child Neurology, 15, 616–627.Google Scholar
  18. Pernow, B., & Waldenstrom, J. (1954). Paroxysmal flushing and other symptoms caused by 5-hydroxytryptamine and histamine in patients with malignant tumors.Lancet, 2, 951.Google Scholar
  19. Pimparkar, B. D., Senesky, D., & Kalser M. H. (1961). Blood serotonin in nontropical sprue.Gastroenterology, 40, 504–506.Google Scholar
  20. Ritvo, E. R., Yuwiler, A., Geller, E., Ornitz, E. M., Saeger, K., & Plotkin, S. (1970). Increased blood serotonin and platelets in early infantile autism.Archives of General Psychiatry, 23, 566–572.Google Scholar
  21. Ritvo, E. R., Yuwiler, A., Geller, E., Plotkin, S., Mason, A., & Saeger, K., (1971). Maturational changes in blood, serotonin levels and platelet counts.Biochemical Medicine, 5, 90–96.Google Scholar
  22. Schain, R. J., & Freedman, D. X. (1961). Studies on 5-hydroxyindole metabolism in autistic and other mentally retarded children.Journal of Pediatrics 58, 315–320.Google Scholar
  23. Stahl, S. M., Woo, D. J., Mefford, I. N., Berger, P. A., & Ciaranello, R. D. (1983). Hyperserotonemia and platelet serotonin uptake and release in schizophrenia and affective disorders.American Journal of Psychiatry, 140, 26–30.Google Scholar
  24. Taylor, D. L., Mathew, R. J., Ho, B. T. & Weinman (1984). Serotonin levels and platelet uptake during premenstrual tension.Neuropsychobiology, 12, 16–18.Google Scholar
  25. Ternaux, J. P., Mattei, J. F., Faudon, M., Barrit, M. C., Ardissone, J. P., & Giraud, F. (1979). Peripheral and central 5-hydroxytryptamine in trisomy 21.Life Sciences, 25, 2017–2022.Google Scholar
  26. Tu, J., & Partington, M. W. (1972). 5-Hydroxyindole levels in the blood and CSF in Down's syndrome, phenylketonuria and severe mental retardation.Developmental Medicine and Child Neurology, 14, 457–466.Google Scholar
  27. Wechsler, D. (1981).Manual for the Wechsler Adult Intelligence, Scale-Revised, New York: Psychological Corp.Google Scholar
  28. Young, S. N., & Ervin, F. R. (1984). Cerebrospinal fluid measurements suggest precursor availability and sex are involved in the control of biogenic amine metabolism in a primate.Journal of Neurochemistry, 42, 1570–1573.Google Scholar
  29. Yuwiler, A., Plotkin, S., Geller, E., & Ritvo, E. R. (1970). A rapid accurate procedure for the determination of serotonin in whole human blood.Biochemical Medicine, 3, 426–436.Google Scholar

Copyright information

© Plenum Publishing Corporation 1988

Authors and Affiliations

  • Edwin H. CookJr.
    • 1
  • Bennett L. Leventhal
    • 1
  • Daniel X. Freedman
    • 1
    • 2
  1. 1.Child and Adolescent PsychiatryUniversity of ChicagoChicago
  2. 2.Neuropsychiatric InstituteUniversity of CaliforniaLos Angeles

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