Journal of Autism and Developmental Disorders

, Volume 18, Issue 4, pp 553–559 | Cite as

Serotonin and measured intelligence

  • Edwin H. CookJr.
  • Bennett L. Leventhal
  • Daniel X. Freedman


Blood serotonin (5HT) has been shown to be elevated in 30% of autistic children and 50% of severely mentally retarded children. Ninety-eight normal adult subjects were studied to determined if there was an inverse relationship between whole blood 5HT in normal adults of average and above-average intelligence. There was a trend toward a negative correlation between whole blood 5HT and Vocabulary scores that would not account for hyperserotonemia in autistic or mentally retarded individuals. Female subjects had significantly greater whole blood 5HT than male subjects. There was no difference in whole blood 5HT collected before and after volume depletion of 450 ml, providing further evidence of the intraindividual stability of whole blood serotonin levels. There was no relationship between age and whole blood 5HT in a group of normal adult subjects.


Serotonin Negative Correlation Inverse Relationship School Psychology Male Subject 
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Copyright information

© Plenum Publishing Corporation 1988

Authors and Affiliations

  • Edwin H. CookJr.
    • 1
  • Bennett L. Leventhal
    • 1
  • Daniel X. Freedman
    • 1
    • 2
  1. 1.Child and Adolescent PsychiatryUniversity of ChicagoChicago
  2. 2.Neuropsychiatric InstituteUniversity of CaliforniaLos Angeles

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