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Digestive Diseases and Sciences

, Volume 40, Issue 9, pp 1913–1921 | Cite as

Influence of bradykinin in gastrointestinal disorders and visceral pain induced by acute or chronic inflammation in rats

  • Véronique Julia
  • Théodora Mezzasalma
  • Lionel Buéno
Intestinal Disorders, Inflammatory Bowel Disease, Immunology, and Microbiology

Abstract

This work investigated the role of bradykinin in viscerosensitivity before and during inflammation in two models of visceral pain induced by rectal distension (RD) or “abdominal distension” (AD) in rats. RD induced both inhibition of colonic motility and an increase of abdominal spike bursts. Bradykinin receptor antagonist, Hoe 140 did not affect any of the RD-induced responses. After TNB-induced rectal inflammation, colonic inhibition and the number of abdominal contractions were enhanced. Hoe 140 selectively reduced the abdominal response to the highest distension volume, without affecting the colonic response. In AD group, acetic acid inhibited gastric emptying and increased the number of abdominal ontractions, whereas the same volume of saline did not affect any of the responses. Before inflammation, Hoe 140 (1–5 mg/kg, intraperitoneally) did not affectper se abdominal and gastric emptying responses; in contrast, at 5 mg/kg, intraperitoneally, it reduced significantly (P<0.05) both acetic acid-induced responses. We conclude that bradykinin is involved in viscerosensitivity changes related to abdominal and rectal distension in inflammatory conditions.

Key Words

rectal distension motility gastric emptying rat inflammation visceral pain 

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References

  1. 1.
    Starr MS, West GB: Bradykinin and oedema formation in heated paws of rats. Br J Pharmacol 31:178–187, 1967Google Scholar
  2. 2.
    Hargeaves KM, Troullos ES, Dionnes RA, Schmidt EA, Schafer SC, Jorris JL: Bradykinin is increased during acute and chronic inflammation: therapeuthic implications. Clin Pharmacol Ther 44:613–621, 1988PubMedGoogle Scholar
  3. 3.
    Barthon JM, Proud D: Bradykinin antagonists. Annu Rev Toxicol 31:129–162, 1991Google Scholar
  4. 4.
    Regoli D, Barabe J: Pharmacology of kinins. Pharmacol Rev 32:1–46, 1980PubMedGoogle Scholar
  5. 5.
    Steranka LR, Dehaas CJ, Vavrek RJ, Stewart JM, Enna SJ, Snyder SH: Antinociceptive effects of bradykinin antagonists. Eur J Pharmacol 136:261–262, 1987PubMedGoogle Scholar
  6. 6.
    Correa CR, Calixto JB: Evidence for participation of B1 and B2 kinin receptors in formalin-induced response in the mouse. Br J Pharmacol 110:193–198, 1993PubMedGoogle Scholar
  7. 7.
    Whalley ET, Clegg S, Stewart JM, Vavrek RJ: The effect of kinin agonists and antagonists on the pain response of the human blister base. Naunyn-Schmiedebergs Arch Pharmacol 336:652–655, 1987PubMedGoogle Scholar
  8. 8.
    Chau TT, Lewin AC, Walter TL, Carlson RP, Weichman BM: Evidence for a role of bradykinin in experimental pain models. Agents Actions 34:235–238, 1991PubMedGoogle Scholar
  9. 9.
    Bhoola KD, Figuera CD, Worthy K: Bioregulation of kinins: Kallikreins, kininogens and kininases. Pharmacol Rev 44:1–44, 1992PubMedGoogle Scholar
  10. 10.
    Dray A, Perkins M: Bradykinin and inflammatory pain. Trends Neurosci 16:99–104, 1993PubMedGoogle Scholar
  11. 11.
    Steranka LR, Manning DC, Dehaas CJ, Ferkany JW, Borosky SA, Ryder JR, Vavrek RJ, Stewart JM, Snyder SH: Bradykinin as a pain mediator: Receptors are localized to sensory neurons and antagonists have analgesic actions. Proc Natl Acad Sci USA 85:3245–3252, 1988PubMedGoogle Scholar
  12. 12.
    Hock FJ, Wirth K, Albus U, Linz W, Gerhards HJ, Wiemer G, Henke St, Breipohl G, Konig W, Knolle J, Scholkens BA: Hoe 140 a new potent and long acting bradykinin antagonist; in vitro studies. Br J Pharmacol 102:769–773, 1991PubMedGoogle Scholar
  13. 13.
    Wirth K, Hock FJ, Albus U, Linz W, Anagnostopoulos H, Henke St, Breipohl G, Konig W, Knolle J, Scholkens BA: Hoe 140, a new potent and long acting bradykinin antagonist;in vivo studies. Br J Pharmacol 102:774–777, 1991PubMedGoogle Scholar
  14. 14.
    Ness TJ, Gebhart GF: Colorectal distension as a noxious visceral stimulus: Physiologic characterization of pseudoaffective reflexes in the rat. Br Res 450:153–169, 1988Google Scholar
  15. 15.
    Morteau O, Hachet T, Caussette M, Bueno L: Experimental colitis alters visceromotor response to colorectal distension in awake rats. Dig Dis Sci 39(6):1239–1248, 1994PubMedGoogle Scholar
  16. 16.
    Pairet M, Ruckebusch Y: On the relevance of non-steroidal anti-inflammatory drugs in the prevention of paralytic ileus in rodents. J Pharm Pharmacol 205:547–555, 1989Google Scholar
  17. 17.
    Ruckebusch Y, Fioramonti J: Electrical spiking activity and propulsion in small intestine in fed and fasted rats. Gastroenterology 69:1045–1047, 1975PubMedGoogle Scholar
  18. 18.
    Heapy C, Shaw JS, Farmer SC: Differential sensitivity of antinociceptive assays to the bradykinin antagonist Hoe 140. Br J Pharmacol 108:209–213, 1993PubMedGoogle Scholar
  19. 19.
    Ferrira SH, Lorenzetti BB, Poole S: Bradykinin initiates cytokine-mediated inflammatory hyperalgesia. Br J Pharmacol 110:1227–1231, 1993PubMedGoogle Scholar
  20. 20.
    Geppetti P, Maggi CA, Perretti F, Frilli F, Manzini S: Simultaneous release by bradykinin of substance P and CGRP like immunoreactivities from capsaicin-sensitive structures in guinea pig heart. Br J Pharmacol 94:288–290, 1988PubMedGoogle Scholar
  21. 21.
    Bertrand C, Geppetti P, Piedimonte G, Baker J, Petersson G, Nadel JA: Bradykinin increases permeability in the rat nasal mucosa: Contribution of angiotensin-converting enzyme and neutral peptidase 24.11 Am Rev Respir Dis 154(4):A44, 1992Google Scholar
  22. 22.
    Julia V, Morteau O, Bueno L: Involvement of neurokinin 1 and 2 receptors in viscerosensitive response to rectal distension in rats. Gastroenterology 107:94–102, 1994PubMedGoogle Scholar
  23. 23.
    Chapman V, Dickenson AH: The spinal and peripheral roles of bradykinin and prostaglandins in nociceptive processing in the rat. Eur J Pharmacol 219:427–433, 1992PubMedGoogle Scholar
  24. 24.
    Rangachari PK, Berezin M, Prior T: Effects of bradykinin on the canine on the proximal colon. Regul Pept 46:511–522, 1993PubMedGoogle Scholar
  25. 25.
    Tien XY, Wallace LJ, Kachur JF, Won-Kim S, Gaginella TS: Characterization of Ile, Ser-bradykinin-induced changes in short-circuit current across rat colon. J Pharmacol Exp Ther 254(3):1063–1067, 1990PubMedGoogle Scholar
  26. 26.
    Kuwahara A, Cooke HJ: Tachykinin-induced anion secretion in guinea-pig distal colon: Role of neural and inflammatory mediators. J Pharmacol Exp Ther 252:1–7, 1990PubMedGoogle Scholar
  27. 27.
    Davis AJ, Perkins MN: The involvement of bradykinin B1 and B2 receptor mechanisms in cytokine-induced mechanical hyperalgesia in the rat. Br J Pharmacol 113:63–68, 1994PubMedGoogle Scholar
  28. 29.
    Tiffany CW, Bursch RM: Bradykinin stimulates tumor necrosis factor and interleukin 1 release from macrophages. FEBS Lett 247:189–192, 1989PubMedGoogle Scholar
  29. 30.
    Birell GJ, Mc Queen DS, Igoo A, Grubb BD: Prostanoidinduced potentiation of the excitatory and sensitizing effects of bradykinin on articular mechanoreceptors in the rat ankle joint. Neuroscience 54(2):537–544, 1993PubMedGoogle Scholar
  30. 31.
    Kumazawa T, Mizumura K, Koda H: Involvement of EP3 subtype of prostaglandin E receptors in PGE2-induced enhancement of bradykinin resposne of nociceptors. Brain REs 632:321–324, 1993PubMedGoogle Scholar
  31. 32.
    Kumazawa T, Mizumura K, Koda H: Possible involvement of the EP2 receptor subtype in PGE2-induced enhancement of the heat response of nociceptors. Neurosci Lett 175:71–73, 1994PubMedGoogle Scholar
  32. 33.
    Lerner UH, Brunius G, Anduren I, Berggren PO, Juntti-Berggren L, Modeer: Bradykinin induces a B2 receptormediated calcium signal linked to prostanoid formation in human gingival fibroblasts in vitro. Agents Actions 37:43–52, 1992Google Scholar
  33. 34.
    Griesbacher T, Lembeck F: Effects of the bradykinin antagonist, Hoe 140, in experimental acute pancreatitis. Br J Pharmacol 107:356–360, 1992PubMedGoogle Scholar

Copyright information

© Plenum Publishing Corporation 1995

Authors and Affiliations

  • Véronique Julia
    • 1
  • Théodora Mezzasalma
    • 1
  • Lionel Buéno
    • 1
  1. 1.Department of PharmacologyINRAToulouse cedexFrance

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