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Observations on relationship between hypergastrinemia, multple gastric carcinoids, and pancreatic mass

  • Gastrointestinal Oncology
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References

  1. Tang LH, Miller MD, Goldenring JR, Modlin IM, Hersey SJ: Partial agonism by gastrin for a cholecystokinin receptor mediating persingogen seeretion. Am J Physiol 265:G865-G872. 1993

    Google Scholar 

  2. Bilehik AJ, Zucker KA, Adrian TE, Modlin IM: Amelioration of cholinergic-induced pancreatitis with a selective chlecystokinin receptor antagonist. Arch Surg 125:1546–1549, 1990

    Google Scholar 

  3. Basson MD, Adrian TE, Modlin IM: Effects of cholecystokinin and cholinergie receptor blockade on guinea pig pepsinogen secretion. Scand J Gastroenterol 25:825–833, 1990

    Google Scholar 

  4. Bilchik AJ, Zucker KA, Adrian TE, Sussman J, Modlin IM: Effects of a specific cholecystokinin receptor antagonist in a traumatic model of pancrweatitis. Surg Res Commun 8:47–57, 1990

    Google Scholar 

  5. Modlin IM, Esterline W, Kim H, Golderning JR: Enterochromaflin-like cells and gastric argyrophil carcinoidosis Acta Oncol 30:493–498, 1991

    Google Scholar 

  6. Solcia E, Villami L, Luinetti O, Fiocca R: Proton pump inhibitors, enterochromaflin-like cell growth and Helicobacter pylori gastritis. Aliment Pharmacol Ther 1:25–28, 1993

    Google Scholar 

  7. Solcia E, Rindi G, Havu N, Elm G: Qualitative studies of gastric evdocrine cells in patients treated long-term with oneprazole. Scand J Gastroenterol Suppl 166:129–137, 1989

    Google Scholar 

  8. Lamberts R, Creutzifeld W, Stockman F: Long term omeprazole treatment in man: effects on gastric endocrine cell populations. Digestion 47:126–135, 1988

    Google Scholar 

  9. Lamberts R, Creutzfeld W, Struber HG: Long term omeprazole therapy in peptic ulcer disease: Gastrin, endocrine cell growth, and gastritis. Gastroenterology 104:1356–1370, 1993

    Google Scholar 

  10. Godwin JD: Carcinoid tumors: an analysis of 2837 cases. Cancer 36:560–569, 1975

    Google Scholar 

  11. Creutzfeldt W, Stockmann F: Carcinoids and carcinoid syndrome. Am J Med 82:4–16, 1987

    Google Scholar 

  12. Sjoblom SM: Clinical presentation and prognosis of gastrointestinal carcinoid tumours. Scand J Gastroenterol 23:779–787, 1988

    Google Scholar 

  13. Hirschowitz BI, Griffith J, Pellegrin D, Cummings OW: Rapid regression of enterochromaflinlike cell gastric carcinoids in perncicious anemia after antrectomy. Gastroenterology 102:1409–1418, 1992

    Google Scholar 

  14. Rindi G, Luinetti O, Cornaggia M, Capella C, Solcia E: Three subtypes of gastric argyrophil carcinoid and the gastric neuroendocrine carcinoma: a clninicopathologic study. Gastroenterology 194:994–1006, 1993

    Google Scholar 

  15. Lehtoda J, Lkarttunen T, Krekela I, Niemeda S, Rasanen O: Gastric carcinoids withi minimal or no macroscopic lesion in patients with pernicious anemia. Hepato-Gastroenterology 32:72–76, 1985

    Google Scholar 

  16. Borch K: Epidemiologic, clinicopathologic, and economic aspects of gastroscopic screening of patients with pernicious anemia. Scand J Gastroenterol 21:21–30, 1986

    Google Scholar 

  17. Sjoblom SM, Sipponen P, Miettinen M, Karonen SL, Jarvinen HJ: Gastroscopic screening for gastric carcinoids and carcinoma in pernicious anemia. Endoscopy 20:52–56, 1988

    Google Scholar 

  18. Borch K, Renvall H, Liedberg, G: Gastric endocrine cell hyperplasia and carcinoid tumors in pernicious anemia. Gastroenterology 88:638–648, 1985

    Google Scholar 

  19. Bordi C, D'Adda T, Pilato FP, Azzoni C, Caruana P, Gastric carcinoid: A human model of hormane-dependent tumor. Acta Bimomed Ateneo Paramense 62:57–65, 1991

    Google Scholar 

  20. Dayal Y: Hyperplastic proliferations of the ECL cells. Yale J Biol Med 65:805–825, 1992

    Google Scholar 

  21. Solcia E, Fiocca R, Villani L, Gianatti A, Cornaggia M, Chiaravalli A, Curzio M, Capella C: Morphlogy and pathogenesis of endocrine hyperplasia, precarcinoid lesions, and carcinoids arising in crhonic atrophic gastritis. Scand J Gasroenterol Suppl 180:146–159, 1991

    Google Scholar 

  22. Stolte M, Ebert D, Seifert E, Schulte F, Rode J: The prognosis of carcinoid tumors of the stomach: Leber Magen Darm 18:246–250, 1988

    Google Scholar 

  23. Cadot G, Laurent-Puig P, Thuille B, Lehy T, Mignon M. Olschwang S: Is the multiple endocrine neoplasia type 1 gene a suppressor for fundic argyrophil tumors in the Zollinger-Ellison syndrome. Gastroenterology 105:579–582, 1993

    Google Scholar 

  24. Lehy T, Cadiot G, Mignon M, Ruszniewski P, Bonfils S: Influence of multiple endocrine neoplasia type 1 on gastric endocrine cells in patients with Zollinger-Ellison syndrome. Gut 33:1275–1279, 1992

    Google Scholar 

  25. Solcia E, Capella C, Fiocca R, Rindi G, Rosai J: Gastric argyrophil carcinoidosis in patients with Zollinger-Ellison syndrome due to type 1 multple endocrine neoplasia. A newley recognized assoication. Am J Surg Pathol 14:503–513, 1990

    Google Scholar 

  26. Solcia E, Rindi G, Silini E, Villani L: Enterochromaffin-like (ECL) cells and their growths: Relationsiphips to gastrin, reduced acid secretion and gastritis. Baillieres Clin Gastroenterol 7:149–165, 1993

    Google Scholar 

  27. Mizuma K, Shibuya H, Totsuka M, Hayasaka H: Carcinoid of the stomach: A case report and review of 100 cases reported ibn Japan: Ann Chir Gynaecol 72:23–27, 1983

    Google Scholar 

  28. Ahlman H, Dahlstrom A, Enerback L, Granerus G, Nilsson O. Persson S, Tisell LE: Two cases of gastric carcinoids: Diagnostie acn therapeutie aspects. World J Surg 12:356–361, 1988

    Google Scholar 

  29. Ahlman H, Wangberg B, Nilsson O, Grimelius L, Granerus G, Modlin IM, Stenqvist O, Schersten T: Aspects on diagnosis and treatment of the foregut carcinoid syndrome. Scand J Gastroenterol 27:459–471, 1992

    Google Scholar 

  30. Nakamura S, Lida M, Yao T, Fujishima M: Endocscopic features of gastric carcinoids. Gastrointest Endose 35:535–538. 1991

    Google Scholar 

  31. Giovannini M, Seitz JF, Thomas P, Houvenaeghel G, Delpero JR, Giudicelli R, Fuentes P: Electronie sectorial ultrasound endoscopy in benign and malignant tumoral pathology of the stomach. Results in 30 patients. Gastroenterol Clin Biol 17:26–32, 1993

    Google Scholar 

  32. Johansson H, Wilander E: A clinical study of 30 gastric carcinoids. Upsala J Med Sci 87:135–142, 1982

    Google Scholar 

  33. Kuyer PP, Rosenbusch G, Yap SH, de Boer HH: The variable picture of gastric carcinoid ROFO: Fortsch Geb Roentgenstr Nuklearmed 34:184–188, 1987

    Google Scholar 

  34. Naitoh H, Kumashiro R, Teshima K, Oku K, Inutsuka S, Egashira K, Murayama H: A minute, solitary carcinoid of the stomach with a lymph node metastasis—a case report. Gas No Rinsho 34:908–913, 1988

    Google Scholar 

  35. Picus D, Glazer HS, Levitt RG, Husband JE: Computer tomography of abdominal carcinoid tumors. Am J Roentgenol 143:581–594, 1984

    Google Scholar 

  36. Hurst RD, Modlin IM: Use of radolabeled somatostatin analogs in the identification and treatment of somatostatin receptor-bearing tumors. Digestion 54:88–91, 1993

    Google Scholar 

  37. Joseph K, Stapp J, Reinecke J, Skamel HJ, Hoffken H, Neuhaus C, Lenze H, Trautmann ME, Arnold R. Receptor scintigraphy with111In-pentetreotide for endocrine gastroenteropancreatic tumors. Horm Metab Res Suppl 27:28–35, 1993

    Google Scholar 

  38. Joseph K, Stapp J, Hoffken H, Benning R, Neuhaus C, Trautmann ME, Schwerk WB, Arnold R. Receptor scintigraphy in endocrine gastrointestinal and pancreatic tumors. Dtsch Med Wochenschr 117:1025–1028, 1992

    Google Scholar 

  39. Davis MG, O'Dowd G, McEntee GP, Hennessy TP: Primary gastric carcinoids: A view on management. Br J Surg 77:1013–1014, 1990

    Google Scholar 

  40. Jaffe BM: Surgery for gut hormone-producing tumors. Am J Med. 82:68–76, 1987

    Google Scholar 

  41. De Vries EGE, Kema IP, Sloof MJH, Verschueren RCJ, Kleibeuker JH, Mulder NH, Sleijfer DT, Willemse PJB. Recent developments in diagnosis and treatment of metastatic carcinoid tumors. Scand J Gatroenterol 28:87–93, 1993

    Google Scholar 

  42. Moertel CG, Johnson CM, McKusick MA, Martin J Jr, Nagorney DM, Kvols LK, Rubin J, Kunselman S: The management of patients with advanced carcinoid tumors and islet cell carcinomas. Amnn Intern Med 120:302–309, 1994

    Google Scholar 

  43. Kvols LK, Buck M: Chemotherapy of metastatic carcinoid and islet cell tumors. Am J Med. 82:77–83, 1987

    Google Scholar 

  44. Oberg K, Funa K, Alm G Effects of leukocyte interferon on clinical symptoms and hormone levels in patients with mid-gut carcinoid tumors and carcinoid syndrome N Engl J Med 309:129–132, 1983

    Google Scholar 

  45. Kvols LK: Therapy of the malignant carcinoid syndrome. Endocrinol Metab Clin North Am 18:557–568, 1989

    Google Scholar 

  46. Harvey RF, Bradshaw MJ, Davidson CM, Wilkinson SP, Davies PS: Multifocal gastric carcinoid tumours, achlorhydria, and hypergastrinaemia. Lancet 1:951–954, 1985

    Google Scholar 

  47. Caruso ML, Pilato FP, D'Adda T, Baggi MT, Fucci L, Valentini AM, Lacatena M, Bordi C: Composite carcinoidadenocarcinoma of the stomach associated with multiple gastric carcinoid and nonantral gastric atrophy. Cancer 64:1534–1539, 1989

    Google Scholar 

  48. Eckhauser FE, Lloyd RV, Thompson NW, Raper SE, Vinik AI: Antrectomy for multicentric, argyrophil gastric carcinoids: A preliminary report. Surgery 104:1046–1053, 1988

    Google Scholar 

  49. Richards AT, Hinder RA, Harrison AC: Gastric carcinoid tumours associated with hypergastrinaemia and pernicious anaemia—regression of tumors by antrectomy. A case report. S Afr Med J 72:51–53, 1987

    Google Scholar 

  50. Solcia E, Bordi C, Creutzfeld W, Dayal Y, Dayan AD, Falkmer S, Grimelius L, Havu N: Histopathological classification of nonantral gastric endocrine growths in man. Digestion 41:185–200, 1988

    Google Scholar 

  51. Capella C, Finzi G, Cornaggia M, Usellini L, Luinetti O, Buffa R, Solcia E: Ultrastructural typing of gastric endocrine cells.In The Stomach as an Endocrine Organ. R Hankanson, F Sundler, (eds). Amsterdam. Elsevier Science Publishers, 1991, pp 27–51

    Google Scholar 

  52. Moesta KT, Schlag P: Proposal for a new carcinoid tumour staging system based on tumour tissue infiltration and primary metastasis: a prospective multicentre carcinoid tumour evaluation study. West German Surgical Oncologists' Group. Eur J Surg Oncol 16:280–288, 1990

    Google Scholar 

  53. Kumashiro R, Naitoh H, Teshima K, Sakai T, Inutsuka S: Minute gastric carcinoid tumor with regional lymph node metastasis. Int Surg 74:198–200, 1989

    Google Scholar 

  54. Morise K, Kusugami K, Hayakawa M, Nakata S, Inagaki T, Hayashi N, Kato Y: Minute carcinoid tumor of the stomach: report of two cases and review of the Japanese literature. Gastroenterol Jpn 20:596–603, 1985

    Google Scholar 

  55. Nilsson O, Wangberg B, Johansson L, Modlin IM, Ahlman H.Praomys (Mastomys) natalensis: A model for gastric carcinoid formation. Yale J Biol Med 65:741–751, 1992

    Google Scholar 

  56. Kumazawa H, Takagi H, Sudo K, Nakamura W, Hosoda S: Adenocarcinoma and carcinoid developing spontaneously in the stomach of mutant strains of Mastomys natablensis. Virchows Arch A Pathol Anat Histopathol 416:141–151, 1989

    Google Scholar 

  57. Modlin IM, Nangia AK: The pathobiology of the human enterochromaffin-like cell. Yale Biol Med 65:775–792. 1989

    Google Scholar 

  58. Bilchik AJ, Nilsson O, Modlin IM, Sussman J, Zucker KA, Adria TE: H2-receptor blockade induces peptide YY and enteroglucagon-secreting gastric carcinoids in mastomys. Surgery 106:1119–1126, 1989

    Google Scholar 

  59. Brittain RT, Jack D, Reeves JJ, Stables R: Pharmacological basis for the induction of gastric carcinoid tumours in the rat by loxtidine, and insurmountable histamine H2-receptor blocking Jrug. Br J Pharmacol 85:843–847, 1985

    Google Scholar 

  60. Modlin IM, Kumar R, Nangia A, Soroka CJ, Pasikhov D, Goldenring JR: Gastrin-dependent inhibitory effects of octreotide on the genesis of gastric ECLomas. Surgery 112:1048–1058, 1992

    Google Scholar 

  61. Chiba T, Kinoshita Y, Morishita T, Nakata H, Nakamura A, Hosoda S: Receptors for gastrin on gastric carcinoid tumor membrane ofMastomys natalensis. Biochem Biophys Res Commun 177:739–744, 1991

    Google Scholar 

  62. Nakata H, Matsui T, Ito M, Taniguchi T, Naribayashi Y, Arima N, Nakamura A, Kinoshita Y, Chihara K, Hosoda S, Chiba T: Cloning and characterization of gastrin receptor from ECL carcinoid tumor ofMastomys natalensis. Biochem Biophys Res Commun 187:1151–1157, 1992

    Google Scholar 

  63. Inomoto Y, Kinoshita Y, Nakamura A, Arima N, Yamashita Y, Nakata H, Yamamura Y, Hosoda S, Chiba T: Characterization of gastrin/CCK receptors on gastric carcinoid tumor membrane ofMastomy natalensis. Regul Pept 43:149–158, 1993

    Google Scholar 

  64. Prinz C, Kajimura M, Scott D, Mercier F, Helander H, Sachs G: Histamine secretion from rat enterochromaffin-like cells. Gastroenterology 105:449–461, 1993

    Google Scholar 

  65. Axelson J, Ekelund M, Sundler F, Hakanson R: Enhanced hyperplasia of gastric enterochromaffinlike cells in response to omeprazole-evoked hypergastrinemia in rats with portocaval shunts: An immunocytochemical and chemical study. Gastroenterology 99:635–640, 1990

    Google Scholar 

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Authors and Affiliations

  1. Gastrointestinal Surgical Fathobiology Research Group, Department of Surgery, Yale University School of Medicine, P.O. Box 208062, 06520-5062, New Haven, Connecticut

    Irvin M. Modlin MD, PhD, Christopher J. Gilligan MPhil., Gary P. Lawton MD, Laura H. Tang Md. PhD, A., Brian West MD, MRCPath & Robert Lindenberg MD

  2. West Haven Veterans Administration Medical Center, 06520-5062, New Haven, Connecticut

    Irvin M. Modlin MD, PhD, Christopher J. Gilligan MPhil., Laura H. Tang Md. PhD, A., Brian West MD, MRCPath & Robert Lindenberg MD

  3. Department of Pathology, Yale University School of Medicine, 06520-8062, New Haven, Connecticut

    Irvin M. Modlin MD, PhD, Christopher J. Gilligan MPhil., Gary P. Lawton MD, Gary P. Lawton MD, Laura H. Tang Md. PhD, A., Brian West MD, MRCPath & Robert Lindenberg MD

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  1. Irvin M. Modlin MD, PhD
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  2. Christopher J. Gilligan MPhil.
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  3. Gary P. Lawton MD
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  4. Laura H. Tang Md. PhD, A.
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Modlin, I.M., Gilligan, C.J., Lawton, G.P. et al. Observations on relationship between hypergastrinemia, multple gastric carcinoids, and pancreatic mass. Digest Dis Sci 41, 105–114 (1996). https://doi.org/10.1007/BF02208590

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