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Clinical Rheumatology

, Volume 14, Issue 5, pp 537–543 | Cite as

The clinical and immunological effects of cyclosporin A on patients with rheumatoid arthritis

  • D. M. Chang
  • S. F. Chiao
Article
  • 15 Downloads

Summary

Ten patients with rheumatoid arthritis entered this open study to investigate the clinical and immunological effects of cyclosporin-A (CsA) on rheumatoid arthritis. A dosage of 2.5mg/kg/day was used, and each patient was examined every two weeks. The clinical assessment was performed on the basis of the number of painful and swollen joints, the duration of morning stiffness, and the physician and patient global assessment. The laboratory assessment included blood and urine analysis, liver and renal function, C-reactive protein (CRP), and erythrocyte sedimentation rate. The cell surface markers were determined by flow cytometer. Soluble interleukin-2 (IL-2) receptor and IL-2 production were determined by ELISA. Eight patients continued through the six-month study, and marked improvement was found after three months in all clinical indices except morning stiffness. The laboratory assessment demonstrated significant decrease of CRP af-ter six months treatment. Serum creatinine, though within normal limit, was about 30% above the baseline value. There was no significant change of IL-2R and HLADR expression on T cells during the therapeutic course. However, statistically significant decreases of both IL-2 production from lymphocytes and serum IL-2R concentration were found after 22 weeks treatment. The current studies suggest that CsA is clinically effective in the treatment of rheumatoid arthritis and may act through suppression of T cells.

Key words

Cyclosporin A Rheumatoid Arthritis Interleukin-2 

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Copyright information

© Acta Medica Belgica 1995

Authors and Affiliations

  • D. M. Chang
    • 1
  • S. F. Chiao
    • 2
  1. 1.Division of Rheumatology/Immunology/AllergyTri-Service General Hospital, National Defense Medical CenterTaipeiTaiwan, R.O.C.
  2. 2.Department of Clinical PharmacologyTri-Service General Hospital, National Defense Medical CenterTaipeiTaiwan, R.O.C.

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