Clinical Rheumatology

, Volume 10, Issue 1, pp 43–48 | Cite as

Sulphasalazine in ankylosing spondylitis. A radiological, clinical and laboratory assessment

  • H. G. Taylor
  • E. J. Beswick
  • P. T. Dawes
Originals

Summary

In a 12-month double-blind placebo-controlled trial, the effect of sulphasalazine was studied in 40 patients with ankylosing spondylitis. The treatment group showed significant improvement in pain, stiffness, sleep disturbance (p<0.05), finger/floor distance, erythrocyte sedimentation rate, C-reactive protein, orosomucoid and IgA levels (p<0.01). There was improvement in sleep disturbance (p<0.05), finger/floor distance and erythrocyte sedimentation rate (p<0.01) in the placebo group. Sulphasalazine did not retard radiological progression as measured either by plain X-ray or computerised tomographic scans. Multiple analysis of variance did not show a significant difference in disease activity indicators between the 2 groups.

Key words

Sulphasalazine Ankylosing Spondylitis Disease Modifying Antirheumatic Drug 

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Copyright information

© Acta Medica Belgica 1991

Authors and Affiliations

  • H. G. Taylor
    • 1
  • E. J. Beswick
    • 1
  • P. T. Dawes
    • 1
  1. 1.Staffordshire Rheumatology CentreHaywood HospitalBurslemUK

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