Clinical Rheumatology

, Volume 11, Issue 2, pp 254–260 | Cite as

Inhibition of superoxide anion release from human polymorphonuclear leukocytes by N-acetyl-galactosamine and N-acetyl-glucosamine

  • M. Kamel
  • M. Alnahdi
Originals

Summary

This study shows that N-acetyl-galactosamine and N-acetyl-glucosamine and diminish the production of superoxide anion from cytochalasin-B treated PMNs stimulated with FMLP. Inhibition ranged from 80.9% to 1.8%. N-acetyl-galactosamine was superior to N-acetyl-glucosamine, but both showed their action in a dose — related fashion. The mannosamine may diminish the superoxide production, but without a statistical significance. Other sugars such as L-fucose, D-fucose and D-glucose failed to induce inhibition of superoxide generation. Previous reports showed that sugars interfere with carbohydrates lectins interaction. This study shows that aminosugars can do more than interfere with carbohydrates-lectin interaction. The mechanism is not completely known yet. The question whether aminosugars affect cell-cell interaction, regulation of respiratory burst, inflammatory mediators functions, or the glucose uptake and utilization needs further study.

Key words

Galactosamine Glucosamine Polymorphonuclear Leukocyte Enzyme Secretion Superoxide Anion Rheumatoid Arthritis 

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Copyright information

© Acta Medica Belgica 1992

Authors and Affiliations

  • M. Kamel
    • 1
    • 2
  • M. Alnahdi
    • 3
  1. 1.Department of RheumatologyAzhar UniversityCairoEgypt
  2. 2.Dr. Fakhry HospitalDhahranSaudi Arabia
  3. 3.Department of Internal MedicineKing Faisal UniversityDammamSaudi Arabia

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