Osteoporosis in rheumatoid arthritis: Effect of disease activity
In addition to juxtaarticular osteoporosis, which appears to reflect predominantly local disease mechanisms, more generalized bone loss can occur in rheumatoid arthritis(RA). The aim of this study was to compare bone mineral density (BMD) of the lumbar spine and proximal femur in RA patients versus controls and evaluate the influence of disease related determinants. Twenty-seven patients with RA and twenty healthy subjects were included in this study. BMD was significantly reduced in RA patients compared with the control group. BMD was correlated with duration of disease, health assessment questionnaire scores, hand grip strength and erythrocyte sedimentation rate. These results support the hypothesis that BMD may be affected by RA related determinants.
Key wordsRheumatoid Arthritis Osteoporosis Bone Densitometry
Unable to display preview. Download preview PDF.
- 1.Laan, R.F.J.M., Buijs, W.C.A.M., Verbeek, MA.L.M., Draad, M.P., Corstens, F.H.F., Van de Putte, L.B.A., Van Riel, P.L.C.M. Bone mineral density in patients with recent onset rheumatoid arthritis: Influence of disease activity and functional capacity. Ann Rheum Dis 1993, 52, 21–26.PubMedGoogle Scholar
- 14.Steinbrocker, O., Traeger, C.H., Batterman, R.C. Therapeutic criteria in rheumatoid arthritis. JAMA 1949, 140, 659–662.Google Scholar
- 24.Gevers, G., Devos, P., De Roo, M., Dequeker, J. Increased levels of osteocalcin (Serum bone Gla-protein) in rheumatoid arthritis. Br J Rheum 1986, 25, 260–262.Google Scholar