Summary
Anticardiolipin antibodies (aCL) of immunoglobulin (Ig) G and M classes were determined in 28 patients affected with chronic discoid lupus erythematosus (CDLE), comparing their prevalence and levels to those in 60 healthy subjects matched for age and sex. A high and significant frequency of IgG (67.8%) and IgM (50.0%) aCL together with prevalence of high antibody levels was found in CDLE patients, while healthy controls had IgG and IgM aCL in 1.6% and 3.3% of cases respectively. Clinical features in keeping with the diagnosis of antiphospholipid syndrome were found in one patient (3.5%), which, as the first manifestation of the syndrome, showed a pulmonary thromboembolism which appeared some days after prolonged exposure to the sun. These results provide additional data on autoimmune phenomena in CDLE and suggest that aCL test should be considered as useful aids in immunological diagnosis of CDLE.
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References
Harris, E.N., Khamashta, M.A., Hughes, G.R.V. Antiphospholipid antibody syndrome. In: Arthritis and Allied Conditions, 12th ed., Eds.: McCarthy, D.J.Jr., Koopman, J.W., Philadelphia, Lea and Febiger, 1993, 1201–1212.
Love, P.E., Santoro, S.A. Antiphospholipid antibodies: Anticardiolipin and the lupus anticoagulant in systemic lupus erythematosus (SLE) and in non-SLE disorders. Ann Intern Med 1990, 112, 682–698.
Kind, P., Schuppe, H.C., Jung, K.P., Degitz, K., Lakomek, H.J., Goerz, G. Kutaner Lupus erythematodes und KardiolipinAntikorper. Vorkommen und klinische bedeutung. Hautarzt 1992, 43, 126–129.
Tebbe, B., Orfanos, C.E. Anticardiolipin-antikorper beim Kutanen Lupus erythematodes. Vorkommen und bedeutung als marker vaskularer symptomatik. Hautartz 1992, 43, 130–133.
Tan, E., Cohen, A.S., Fries, J.F. et al. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1982, 25, 1271–1277.
Ackerman, A.B., Superficial and deep perivascular dermatitis. In: Histologic Diagnosis of Inflammatory Skin Diseases, Ed.: Ackerman, A.B., Philadelphia, Lea and Febiger, 1978, 306–315.
Gharavi, A.E., Harris, E.N., Asherson, R.A., Huges, G.R.V. Anticardiolipin antibodies: isotype distribution and phospholipid specificity. Ann Rheum Dis 1987, 46, 1–6.
Weinstein, M.C., Fineberg, H.V. Clinical decision analysis. Philadelphia, Saunders, 1980, 114–127.
Ruffatti, A., De Silvestro, G., Ghirardello, A., et al. A catastrophic antiphospholipid syndrome: the importance of high levels of warfarin anticoagulation. J Intern Med 1994, 235, 81–83.
Lehmann, P., Holze, E., Kind, P., Goerz, G., Plewig, G. Experimental reproduction of skin lesions in lupus erythematosus by UVA and UVB radiation. J Am Acad Dermatol 1990, 22, 181–187.
Lockshin, M.D., Antiphospholipid antibody syndrome. JAMA 1992, 268, 1451–1453.
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Ruffatti, A., Veller-Fornasa, C., Patrassi, G.M. et al. Anticardiolipin antibodies and antiphospholipid syndrome in chronic discoid lupus erythematosus. Clin Rheumatol 14, 402–404 (1995). https://doi.org/10.1007/BF02207672
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DOI: https://doi.org/10.1007/BF02207672