Summary
Bone loss was determined in 178 women in the early postmenopausal period by photon absorptiometry measurement of forearm bone mineral content (BMC) every three months for two years. With a sequential cut-off technique, the results of a single determination of body fat mass, urinary calcium and hydroxyproline, and serum alkaline phosphatase, carried out at the first examination, correctly identified 79% of “fast bone losers” (bone loss > 3 % annually) and 78% of “slow bone losers”. The simple biochemical screening procedure was hereafter tested in a new group of 70 early postmenopausal women, who were followed for two years with measurement of local and total BMC. With this simple approach the majority of women at highest risk of osteoporotic fractures in later life can be identified in the early postmenopausal period and can be started on prophylactic hormone replacement therapy.
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Lindsay, R., Hart, D.M., Aitken, J.M., MacDonald, E.B., Anderson, J.B., Clarke, A.C. Lancet 1967, i, 1038–1041.
Christiansen, C., Christensen, M.S., McNair, P., Hagen, C., Stocklund, K.E., Transbøl, I. Eur J Clin Invest 1980, 10, 272–279.
Weiss, N.S., Ure, C.L., Ballard, J.H., Williams, A.R., Daling, J.R. N Engl J Med 1980, 303, 1195–1198.
Ettinger, B., Genant, H.K., Cann, C.E. Ann Intern Med 1985, 102, 319–324.
Christiansen, C., Riis, B.J., Rødbro, P. Lancet 1987, i, 1105–1108.
Christiansen, C., Rødbro, P., Jensen, H. Scand J Clin Lab Invest 1975, 35, 323–330.
Rickers, H., Balslev, I., Foltved, H., Rødbro, P. Acta Med Scand 1981, 209, 203–207.
Christiansen, C., Rødbro, P. Scand J Clin Lab Invest 1977, 37, 321–323.
Gotfredsen, A., Als, O., Tjellesen, L., Nilas, L., Borg, J., Christiansen, C. J Comput Assist Tomogr 1983, 7, 558–559.
Johansen, J.S., Mølholm Hansen, J.E., Christiansen, C. Acta Endocrinol 1987, 114, 410–416.
Pødenphant, J., Larsen, N-E., Christiansen, C. Clin Chim Acta 1984, 142, 145–148.
Gotfredsen, A., Borg, J., Nilas, L., Tjellesen, L., Christiansen, C. Eur J Clin Invest 1986, 16, 198–203.
Als, O.S., Gotfredsen, A., Christiansen, C. Arthritis Rheum 1985, 28, 369–375.
Tjellesen, L., Gotfredsen, A., Borg, J., Christiansen, C. Clin Physiol 1983, 3, 359–364.
Gotfredsen, A., Nilas, L., Riis, B.J., Thomsen, K., Christiansen, C. Br Med J 1986, 292, 1098–1100.
Riis, B.J., Thomsen, K., Christiansen, C. N Engl J Med 1987, 316, 173–177.
Johansen, J.S., Riis, B.J., Delmas, P.D., Christiansen, C. Eur J Clin Invest 1987, accepted.
Ott, S.M., Kilcoyne, R.F., Chesnut III, C.H. Calcif Tissue Int 1986, 39, 133–138.
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Christiansen, C., Riis, B.J. New methods for identifying “at risk” patients for osteoporosis. Clin Rheumatol 8 (Suppl 2), 52–55 (1989). https://doi.org/10.1007/BF02207234
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DOI: https://doi.org/10.1007/BF02207234