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Clinical Rheumatology

, Volume 11, Issue 3, pp 410–412 | Cite as

A case of Raynaud's disease with uterine cancer producing interleukin-6

  • A. Murashima
  • Y. Takasaki
  • H. Hashimoto
  • T. Hirano
  • S. Hirose
Case Report

Summary

A case of cervical cancer of the uterine producing interleukin-6(IL-6) in a patient who suffered from Raynaud's phenomenon is described. Her serum contained anti SS-A antibody. The cancer was removed surgically. High level of IL-6 activity was detected in the culture supernatant of the resected cancer cells. After operation, Raynaud's phenomenon had improved and anti SS-A antibody had disappeared. This case shows us that IL-6 produced by malignant tumour might induce autoimmune connective tissue disease-like symptoms.

Key words

Cervical Cancer of the Uterine Interleukin-6(IL-6) Raynaud's Phenomenon Anti SS-A Antibody 

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Copyright information

© Acta Medica Belgica 1992

Authors and Affiliations

  • A. Murashima
    • 1
  • Y. Takasaki
    • 1
  • H. Hashimoto
    • 1
  • T. Hirano
    • 2
  • S. Hirose
    • 1
  1. 1.Division of Rheumatology, Department of Internal MedicineJuntendo University, School of MedicineTokyoJapan
  2. 2.Division of Immunology, Institute for Cellular and Molecular BiologyOsaka UniversityOsakaJapan

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