Summary
Serum levels of the soluble form of the interleukin-2 receptor (sIL-2R) were measured in the sera of 32 patients with systemic lupus erythematosus. A significant correlation was observed between the levels of sIL-2R and the SLAM score of disease activity (R:0.40; p:<0.05). The correlation was slightly lower than those between the SLAM score and the levels of anti-dsDNA or of the complement activity. The levels of sIL-2R were not significantly correlated with those of serum anti-ds-DNA and complement, nor with a sign of peripheral blood B cell hyperactivity, such as the spontaneous in vitro production of anti-DNA antibodies.
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References
Blaese, R.M., Grayson, J., Steinberg, A.D. Elevated immunoglobulin secreting cells in the blood of patients with active systemic lupus erythematosus: correlation of laboratory and clinical assessment of disease activity. Am J Med 1980, 69, 345–9.
Lloyd, W., Schur, P.H. Immune complexes, complement, and anti-DNA in exacerbations of systemic lupus erythematosus. Medicine 1981, 60, 208–18.
Liang, M.H., Socher, S.A., Robert, W.N., Esdaile, J.E. Measurement of systemic lupus erythematosus activity in clinical research. Arthritis Rheum 1988, 31, 817–25.
Rubin, L.A., Kurman, C.C., Fritz, M.E., Biddison, W.E., Boutin, B., Yarchoan, R., Nelson, D.L. Soluble interleukin 2 receptors are released from activated human lymphoid cells in vitro. J Immunol 1985, 135, 3172–7.
Rubin, L.A. The soluble interleukin-2 receptor in rheumatic disease. Arthritis Rheum 1990, 33, 1145–8.
Wolf, R.E., Brelsford, W.G. Soluble interleukin-2 receptors in systemic lupus erythematosus. Arthritis Rheum 1988, 31, 729–35.
Campen, D.H., Horwitz, D.A., Quismorio, F.P., Ehresmann, G.R., Martin, W.J. Serum levels of interleukin-2 receptor and activity of rheumatic diseases characterized by immune system activation. Arthritis Rheum 1988, 31, 1358–64.
Huang, Y.P., Perrin, L.H., Miescher, P.A., Zubler, R.H. Correlation of T and B cell activities in vitro and serum IL-2 levels in systemic lupus erythematosus. J Immunol 1988, 141, 827–33.
Semenzato, G., Bambara, L.M., Biasi, D., Frigo, A., Vinante, F., Zuppini, B., Trentin, L., Feruglio, C., Chilosi, M., Pizzolo, G. Increased serum levels of soluble interleukin-2 receptor in patients with systemic lupus erythematosus and rheumatoid arthritis. J Clin Immunol 1988, 8, 447–52.
Manoussakis, M.N., Papadopoulos, G.K., Drosos, A.A., Moutsopoulos, H.M. Soluble interleukin 2 receptor molecules in the serum of patients with autoimmune diseases. Clin Immunol Immunopathol 1989, 50, 321–32.
Tokano, Y., Murashima, A., Takasaki, Y., Hasimoto, H., Okuhura, K., Hirose, S. Relation between soluble interleukin 2 receptors and clinical findings in patients with systemic lupus erythematosus. Ann Rheum Dis 1989, 48, 803–9.
Ter Borg, E.J., Horst, G., Limburg, P.C., Kallemberg, C.G.M. Changes in plasma levels of interleukin-2 receptor in relation to disease exacerbations and levels of anti-dsDNA and complement in systemic lupus erythematosus. Clin Exp Immunol 1990, 82, 21–6.
Liang, M.H., Socher, S.A., Larson, M.G., Schur, P.H. Reliability and validity of six systems for the clinical assessment of disease activity in systemic lupus erythematosus. Arthritis Rheum 1989, 32, 1107–18.
Tan, E.M., Cohen, A.S., Fries, J.F., Masi, A.T., McShane, D.J., Rothfield, N.F., Schaller, J.G., Talal, N., Winchester, R.J. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1982, 25, 1271–7.
American Rheumatism Association Glossary Committee. Dictionary of the rheumatic diseases. Vol I. New York, Contact Associates, 1982.
Aarden, L.A., Lakmaker, F., Feltkamp, T.E.W. Immunology of DNA. I. The influence of reaction condition on the Farr assay used for detection of anti-dsDNA. J Immunol Methods 1976, 10, 27–36.
Lachmann, P.J., Hobarth, M.J., Aston, W.P. Complement technology. In: Handbook of Experimental Immunology. Ed: Weir, D.M. Blackwell Scientific Publication, Oxford, 1974, vol 1, 1–17.
Gorla, R., Airô, P., Franceschini, F., Stefani, E., Braga, S., Tincani, A., Cattaneo, R. Decreased number of peripheral blood CD4+CD29+ lymphocytes and increased in vitro spontaneous production of anti-DNA antibodies in patients with active systemic lupus erythematosus. J Rheumatol 1990, 17, 1048–53.
Takeuchi, T., Abe, T., Hosono, O., Morimoto, C., Homma, M. Cellular mechanisms of DNA-specific antibody synthesis by lymphocytes from systemic lupus erythematosus patients. Arthritis Rheum 1984, 27, 766–73.
Rubin, L.A., Jay, G., Nelson, D.L. The released interleukin 2 receptor binds interleukin 2 efficiently. J Immunol 1986, 137, 3841–4.
Nelson, D.L., Rubin, L.A., Kurman, C.C., Fritz, M.E., Boutin, B. An analysis of the cellular requirements for the production of soluble interleukin-2 receptors in vitro. J Clin Immunol 1986, 6, 114–20.
Balderas, R.S., Josimovic-Alasevic, O., Diamantstein, T., Dixon, F.J., Theofilopoulos, A.N. Elevated titers of cell-free interleukin-2 receptor in serum of lupus mice. J Immunol 1987, 139, 1496–500.
Manoussakis, M.N., Germanidis, G.S., Drosos, A.A., Motsopoulos, H.M. Deficient urinary excretion of soluble IL-2 receptors (sIL-2R) in autoimmune patients. Clin Rheumatol 1990, 9, 130.
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Airô, P., Braga, S., Prati, E. et al. Evaluation of serum levels of soluble interleukin-2 receptor as an indicator of disease activity in systemic lupus erythematosus. Clin Rheumatol 11, 97–100 (1992). https://doi.org/10.1007/BF02207093
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DOI: https://doi.org/10.1007/BF02207093