Agents and Actions

, Volume 5, Issue 4, pp 394–400 | Cite as

The systematic appraisal of cellular injury

  • Judie R. Walton
Models in Toxicology


From a study of the ultrastructural effects of numerous injurious agents on cultured kidney and liver cells, a check-list has been drawn up which summarizes all of the changes observed in subcellular components. The checklist resembles a multiple-choice test. Its use would permit greater standardization abserved in injured cells. It would also increase the objectivity with which cell injury can be assessed by electron microscopy. The checklist is suitable for use in computer-based programs designed to characterize types of cellular injury and for seeking correlations in ultrastructural changes arising from different forms of treatment.


Electron Microscopy Liver Cell Cell Injury Ultrastructural Change Cellular Injury 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. [1]
    J. R. Walton andI. K. Buckley,Cell Models in the Study of Mechanisms of Toxicity, Agents and Actions5, 69–88 (1975).PubMedGoogle Scholar
  2. [2]
    H. R. Kinns andJ. R. Walton,Computer Analysis in the Electron Microscopic Assessment of Cellular Injury, compt. biol. Med. (accepted for publication, 1975).Google Scholar
  3. [3]
    D. R. Myron andJ. L. Connelly,The Morphology of the Swelling Process in Rat Liver Mitochondria, J. Cell Biol.48, 291–302 (1971).Google Scholar

Copyright information

© Birkhäuser-Verlag 1975

Authors and Affiliations

  • Judie R. Walton
    • 1
  1. 1.Department of Experimental Pathology, John Curtin School of Medical ReseachThe Australian National UniversityCanberraAustralia

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