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, Volume 5, Issue 4, pp 311–314 | Cite as

The effects of histamine liberators and exogenous histamine on wound healing in rat

  • R. Dabrowski
  • Cz. Maśliński
  • P. Górski
Histamine and Kinins Research Reports


The effects of compound 48/80, adenosine-5-triphosphate (ATP) and exogenous histamine (Hi) on the healing of excised surface wound and tensile strength of surgical skin wound in rat were studied.

The chemicals were injected directly into the wounded area. 48/80, ATP and exogenous Hi were found to stimulate the wound healing as measured by collagen formation, tensile strength examination and a measurement of the surface circular wound. When given separately, the order of activities was: 48/80>ATP>Hi; when administered together as a mixture, compound 48/80, ATP and exogenous Hi also accelerated the wound healing. The mixture shortened the healing process by about 5 days as compared with 17 days in control.


Collagen Tensile Strength Histamine Wound Healing Healing Process 
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Copyright information

© Birkhäuser-Verlag 1975

Authors and Affiliations

  • R. Dabrowski
    • 1
    • 2
  • Cz. Maśliński
    • 1
    • 2
  • P. Górski
    • 1
    • 2
  1. 1.Department of Pathophysiology, Institute of PathologySchool of MedicinełódźPoland
  2. 2.Department of Biogenic AminesMolecular Research Center of Polish Academy of SciencesŁódźPoland

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