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Automated production of carbon-11 labelled acetate to allow detection of transient myocardial ischemia in man, using positron emission tomography

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Abstract

The synthesis of11C-acetate has been achieved via carbonation of methyl magnesium bromide with11C-labelled carbon dioxide. Using this procedure, 7.4 GBq /200 mCi/ of11CO2 produced by the14 N/P,α/11C nuclear reaction, was converted, within 20 min into11C-acetate with an activity higher than 2.22 GBq /60 mCi/. Chemical and biologic quality control shows that the product is pure, sterile, and pyrogen-free and therefore suitable for human use. Handling considerable amounts of activity has led us to automate the11C-acetate synthesis. The different parts of the system-programmable controller, sensors, automatic neutralization system-are described in detail.

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Authors and Affiliations

  1. Centre de Recherches de Cyclotron /C.R.C./, Université de Liège, Sart Tilman, B-4000, Liège, Belgium

    G. Del Fioe, J. M. Peters, L. Quaglia, J. L. Piette, R. Cantineau, C. De Landsheere, D. Raets & P. Rigo

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  1. G. Del Fioe
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  2. J. M. Peters
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  3. L. Quaglia
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  4. J. L. Piette
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  5. R. Cantineau
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  6. C. De Landsheere
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  7. D. Raets
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  8. P. Rigo
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Del Fioe, G., Peters, J.M., Quaglia, L. et al. Automated production of carbon-11 labelled acetate to allow detection of transient myocardial ischemia in man, using positron emission tomography. Journal of Radioanalytical and Nuclear Chemistry Letters 87, 1–13 (1984). https://doi.org/10.1007/BF02204318

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  • DOI: https://doi.org/10.1007/BF02204318

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