World Journal of Urology

, Volume 15, Issue 5, pp 306–309 | Cite as

Periurethral collagen injection for male and female sphincteric incontinence: indications, techniques, and result

  • Edward J. McGuire
  • Sharon F. English


Intrinsic sphincter deficiency is characterized by a poorly functioning intrinsic urethral sphincter, which leaks urine at relatively low pressures. Patients with this sort of incontinence are candidates for collagen implant therapy. Collagen is injected in the region of the bladder neck with success, depending on the precise placement of the collagen. There is generally a need to implant more collagen into men. The percentage of patients showing improvement in their incontinence after therapy is 58-100%. Over time the collagen is absorbed and there is a need to repeat the treatment. Collagen increases the abdominal leak-point pressure without reducing the flow rate or increasing the residual volume. Treatment failure does not prevent the performance of other procedures.


Public Health Collagen Treatment Failure Bladder Neck Residual Volume 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Aboseif SR, O'Connell HE, Usui A, McGuire EJ (1996) Collagen injection for intrinsic sphincter deficiency in men. J Urol 155: 10–13Google Scholar
  2. 2.
    Armstrong R, Cooperman LS, Parkinson TM, Piez KA (1982) Injectable collagen for soft tissue augmentation. In: Boretos JW, Eden M (eds) Contemporary Biomaterials: Material and Host Response, Clinical Applications, New technologies and legal aspects. Chapter 25, pp. 528–536Google Scholar
  3. 3.
    Cespedes RD, Cross CA, McGuire EJ, O'Connell HE (1996) Collagen injection therapy for the treatment of male urinary incontinence (abstract 588). J Urol 155: 458A (suppl.)Google Scholar
  4. 4.
    Cross CA, Cespedes DA, McGuire EJ (1997) Long-term follow-up of transurethral collagen therapy for urinary incontinence. J Urol (in press)Google Scholar
  5. 5.
    Cummings JM, Boulier JA, Parra RO (1996) Transurethral collagen injections in the therapy of post-radical prostatectomy stress incontinence. J Urol 155: 1011–1013Google Scholar
  6. 6.
    Eckford SD, Abrams P (1991) Para-urethral collagen implantation for female stress incontinence. Br J Urol 68: 586–589Google Scholar
  7. 7.
    Faerber GJ (1996) Endoscopic collagen injection therapy in elderly woman with type I stress urinary incontinence. J Urol 155:512–514Google Scholar
  8. 8.
    Kieswetter H, Fischer M, Wober L, Flamm J (1992) Endoscopic implantation of collagen (GAX) for the treatment of urinary incontinence. Br J Urol 69: 22–25Google Scholar
  9. 9.
    Monga AK, Robinson D, Stanton SL (1995) Periurethral collagen injections for genuine stress incontinence: a 2-year followup. Brit J Urol 76: 156–160Google Scholar
  10. 10.
    Moore KN, Chetner MP, Metcalfe JB, Griffiths DJ (1995) Periurethral implantation of glutaraldehyde cross-linked collagen (Contigen) in woman with type I or III stress incontinence: quantitative outcome measures. Br J Urol 75: 359–363Google Scholar
  11. 11.
    Murless BC (1938) The injection treatment of stress urinary incontinence. J Obstet Gynaecol Br Emp 45: 67–73Google Scholar
  12. 12.
    Neal DE, Lahaye ME, Lowe DC (1995) Improved needle placement technique in periurethral collagen injection. Urology 45:865–866Google Scholar
  13. 13.
    Remacle M, Marbix E (1988) Collagen implants in the human larynx: pathological examination of two cases. Arch Otorhinolaryngol 245: 203–205Google Scholar
  14. 14.
    Stricker P, Haylen B (1993) Injectable collagen for type 3 female stress incontinence: the first 50 Australian patients. Med J Aust 158: 89–91Google Scholar
  15. 15.
    Winters JC, Appell R (1995) Periurethral injection of collagen in the treatment of intrinsic sphincteric deficiency in the female patient. Urol Clin North Am 22: 673–678Google Scholar

Copyright information

© Springer-Verlag 1997

Authors and Affiliations

  • Edward J. McGuire
    • 1
  • Sharon F. English
    • 1
  1. 1.Division of UrologyUniversity of Texas Medical School at HoustonHoustonUSA

Personalised recommendations