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Experientia

, Volume 16, Issue 1, pp 21–24 | Cite as

Partialsynthese des Aldosterons

  • K. Heusler
  • J. Kalvoda
  • Ch. Meystre
  • P. Wieland
  • G. Anner
  • A. Wettstein
  • G. Cainelli
  • D. Arigoni
  • O. Jeger
Kurze Mitteilungen

Summary

The preparation of the (18 → 11β)-lactone ofΔ5-3-ethylenedioxy-11β-hydroxy-21-acetoxy-20-oxo-pregnen-18-oic acid (XV) is reported. Since this compound has previously been transformed into aldosterone, the reactions described represent the first partial synthesis of this important hormone from readily available 18-unsubstituted natural steroids.

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Copyright information

© Birkhäuser Verlag 1959

Authors and Affiliations

  • K. Heusler
    • 1
    • 2
  • J. Kalvoda
    • 1
    • 2
  • Ch. Meystre
    • 1
    • 2
  • P. Wieland
    • 1
    • 2
  • G. Anner
    • 1
    • 2
  • A. Wettstein
    • 1
    • 2
  • G. Cainelli
    • 1
    • 2
  • D. Arigoni
    • 1
    • 2
  • O. Jeger
    • 1
    • 2
  1. 1.Forschungslaboratorien der CIBA Aktiengesellschaft, Pharmazeutische AbteilungBasel
  2. 2.Organisch-chemisches Laboratorium der Eidg. Technischen HochschuleZürich

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