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Untersuchungen an Ionenaustauschmodellen zum Verständnis der Physiologie biogener Amine. Austauschversuche an einem schwefelsäuregruppentragenden Harz zum Verständnis von sogenannten Histaminliberationsvorgängen

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Summary

Mixtures of histamine and other basic substances as hydrochlorides were added in equivalent amounts to an acid ion exchange system containing SO4-groups in the H+-form (Dowex 50 W × 2). After completion of the equilibrium, the amounts of both the free histamine and the competing substance were determined by potentiometric titration.

Values are presented for the relative amounts of each substance which are retained by the resin.

The results obtained show that histamine and a given competing substance are selectively distributed on the resin. The method may be useful as a test for the possible histamine-liberating capacity of biologically important substances.

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Literatur

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Authors and Affiliations

  1. Forschungslaboratorium der CIBA Aktiengesellschaft, Pharmazeutische Abteilung, Basel

    K. Küttner, H. Majer, G. Huber & R. Jaques

Authors
  1. K. Küttner
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  2. H. Majer
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  3. G. Huber
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  4. R. Jaques
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Küttner, K., Majer, H., Huber, G. et al. Untersuchungen an Ionenaustauschmodellen zum Verständnis der Physiologie biogener Amine. Austauschversuche an einem schwefelsäuregruppentragenden Harz zum Verständnis von sogenannten Histaminliberationsvorgängen. Experientia 17, 371–372 (1961). https://doi.org/10.1007/BF02201771

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  • DOI: https://doi.org/10.1007/BF02201771

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