Skip to main content
SpringerLink
Log in

Nitrosamines and other carcinogens as agents of protein denaturation

  • Kurze Mitteilungen
  • Published:
Experientia Aims and scope Submit manuscript

Résumé

Les auteurs montrent que les composés cancérogènes hydrosolubles, l'acide tannique, le phénol, la diéthyl-et diméthylnitrosamine, la thioacétamide, le carbamate d'éthyl et la thiourée sont des agents puissants de dénaturation de protéines. La précipitation produite par ces agents peut être inhibée, inversée ou accrue par divers réactifs de groupes sulfhydryles. Ces recoupements, ainsi que d'autres expériences sur l'effet de l'urée sur la précipitation par la diméthylnitrosamine, indiquent que le mécanisme de la formation des aggrégats moléculaires consiste dans l'établissement de ponts -S-S- intermoléculaires, probablement renforcés par des liaisons intermoléculaires d'hydrogène.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Literatur

  1. P. Rondoni, Adv. Cancer Res.3, 171 (1955).

    Article  CAS  Google Scholar 

  2. E. J. Ambrose, Brit. J. Cancer8, 259 (1954).

    Article  CAS  Google Scholar 

  3. N. P. Buu-Hoï, Acta Union Int. contre Cancer7, 68 (1950).

    Google Scholar 

  4. J. C. Arcos andM. Arcos, Bull. Soc. Chim. Belges65, 5 (1956).

    Article  CAS  Google Scholar 

  5. R. Mason, Brit. J. Cancer12, 469 (1958).

    Article  CAS  Google Scholar 

  6. J. L. Hartwell,Survey of Compounds which Have Been Tested Carcinogenic Activity (U.S. Government Printing Office, Washington (D.C.) 1951).

    Google Scholar 

  7. P. N. Magee andJ. M. Barnes, Brit. J. Cancer10, 114 (1956).

    Article  CAS  Google Scholar 

  8. D. Schmähl andR. Preussmann, Naturwiss.47, 89 (1960).

    Article  Google Scholar 

  9. K. Hohl, Exper.3, 109 (1947).

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Research Laboratory, U.S. Public Health Service Hospital, Departments of Medicine and Biochemistry, Tulane University, New Orleans, Louisiana

    Mary F. Argus, Charlotte J. Leutze & Judith F. Kane

  2. Cancer Research Laboratory, University of Florida, Gainesville, Florida

    Mary F. Argus, Charlotte J. Leutze & Judith F. Kane

Authors
  1. Mary F. Argus
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Charlotte J. Leutze
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Judith F. Kane
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

This work was supported by USPHS Grant CY-4939 at the University of Florida, and by USPHS Grant C-5431 and a Grant-in-aid from the Greater New Orleans Cancer Association and the Cancer Society of Greater Baton Rouge, at Tulane University.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Argus, M.F., Leutze, C.J. & Kane, J.F. Nitrosamines and other carcinogens as agents of protein denaturation. Experientia 17, 357–359 (1961). https://doi.org/10.1007/BF02201761

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02201761

Keywords

Search

Navigation