Abstract
Codon CUG is used for serine instead of for leucine, its usual assignment, in several yeasts of the genusCandida. We propose a series of steps for the reassignment, including disappearance of leucine CUG and its anticodon CAG, formation of a new serine tRNA, with anticodon CAG, from a duplication of the gene for serine tRNA (IGA), and then production of CUG codons by mutation at sites that are mostly “nonessential.”
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References
Kawaguchi Y, Honda H, Taniguchi-Morimura J, Iwasaki S (1989) The codon CUG is read as serine in an asporogenic yeast,Candida cylindracea. Nature 341:164–166
Ohama T, Suzuki T, Mori M, Osawa S, Ueda T, Watanabe K, Nakase T (1993) Non-universal decoding of the leucine codon CUG in severalCandida species. Nucleic Acids Res 21:4039–4045
Osawa S, Jukes TH, Watanabe K, Muto A (1992) Recent evidence for evolution of the genetic code. Microbiol Rev 56:229–264
Santos MAS, Tuite MF (1995) The CUG codon is decodedin vivo as serine and not as leucine inCandida albicans. Nucleic Acids Res 23:1481–1486
Yokogawa T, Suzuki T, Ueda T, Mori M, Ohama T, Kuchino Y, Yoshinari S, Moroki I, Nishikawa K, Osawa S, Watanabe K (1992) Serine tRNA complementary to the nonuniversal serine codon CUG inCandida cylindracea: Evolutionary implications. Proc Natl Acad Sci U.S.A. 89:7408–7411
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Jukes, T.H., Osawa, S. CUG codons inCandida spp.. J Mol Evol 42, 321–322 (1996). https://doi.org/10.1007/BF02198859
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DOI: https://doi.org/10.1007/BF02198859