, Volume 20, Issue 4, pp 323–330 | Cite as

Electrophysiological research into afferent connections of embryonic neocortex allotransplants grafted into the association cortex of adult rats

  • S. V. Girman
  • I. L. Golovina


Grafts of the rat fetal neocortex at the 17–18th day of gestation were placed in the cavity made by aspiration in the primary visual or somatosensory cortex of adult rats. Findings from electrophysiological research performed 3–3.5 months after this transplant showed that neurons of this transplant responded to sensory stimulation specific to the cortical regions replaced by the transplant in 50% of animals. This response was evoked by stimulating local receptive fields displaying a topical organization pattern in a proportion of the animals. Neuronal response in the transplant indicated that the usual field of vision previously existing on the replaced portions of visual cortex had been restored. Electrical stimulation applied locally to a number of brain structures showed that the transplants received afferent inputs from the thalamic nucleus normally projecting to the cortical region replaced by the graft, as well as from homotopic sites on the contralateral cortex. Latencies and time course of neuronal response to stimulating these regions of the host brain resemble those observed in the normal. Afferent inputs from the host brain to cortical transplants thus emulate normal cortical input. Possible mechanisms underlying reinnervation of the grafts are discussed.


Receptive Field Cortical Region Somatosensory Cortex Thalamic Nucleus Neuronal Response 
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Copyright information

© Plenum Publishing Corporation 1989

Authors and Affiliations

  • S. V. Girman
  • I. L. Golovina

There are no affiliations available

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