Behavior Genetics

, Volume 25, Issue 4, pp 371–384 | Cite as

Genetic analysis of the relationships between behavioral and neuroendocrine traits in roman high and low avoidance rat lines

  • Nathalie Castanon
  • Fernando Perez-Diaz
  • Pierre Mormède


In order to determine whether the coselection observed between the selection trait (active avoidance behavior) of the Roman High Avoidance (RHA) and Roman Low Avoidance (RLA) rat lines and their neuroendocrine characteristics were genetically determined, we analyzed, in nonsegregating (RHA, RLA, and F1) and segregating (F2 and the two backcrosses) crosses, the inheritance pattern and the phenotypic correlations among behavioral (shuttle-box behavior), physiological (body, adrenal, and thymus weights), and neuroendocrine (corticosterone and prolactin reactivity, catecholamine enzyme activities) variables. Physiological characteristics and enzyme activities have acrucial role in sex dissociation. Avoidance behavior and prolactin reactivity to novel environment remained associated in segregating crosses despite gene rearrangement. They represented the most important variables to differentiate the Roman lines, perhaps sharing a common regulatory mechanism under genetic control.

Key Words

Roman rat lines adrenal hormones prolactin avoidance behavior tyrosine hydroxylase and phenylethanolamineN-methyl transferase activities segregating crosses multivariate analysis 


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Copyright information

© Plenum Publishing Corporation 1995

Authors and Affiliations

  • Nathalie Castanon
    • 1
  • Fernando Perez-Diaz
    • 2
  • Pierre Mormède
    • 1
  1. 1.Laboratoire de Génétique du Stress et Neurobiologie de l'Adaptation, CJF INSERM 94-05-INRAUniversité de Bordeaux IIBordeauxFrance
  2. 2.Laboratoire de Génétique Neurogénétique et Comportement URA 1294, CNRSUFR. Biomédicale Paris VParis Cedex 06France

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