Calcified Tissue Research

, Volume 6, Issue 1, pp 249–253 | Cite as

Calcium metabolism in response to heparin administration

  • Jenifer Jowsey
  • Peter Adams
  • Allen P. Schlein
Original Papers

Abstract

Heparin was administered to kittens, to intact cats, and to cats whose thyroids, or parathyroids, or both thyroids and parathyroids had been removed. Over 2 or more months, the serum calcium levels rose in all animals. This result, occurring both in the animals lacking thyroids and parathyroids and in those still having them, suggests that the calcium mobilizing effect of heparin was a direct one.

Key words

Calcium Metabolism Heparin Thyroid Parathyroid 

Résumé

De l'héparine est administrée à de jeunes chats, des chats adultes entiers, des chats thyroidectomisés ou parathyroidectomisés et des chats thyroidectomisés et parathyroidectomisés. La calcémie s'est élevée chez tous les animaux pendant 2 ou plusieurs mois. Le fait que ce résultat soit obtenu chez des animaux privés ou en possession de leurs thyroides et parathyroides, indique que l'effet de mobilisation du calcium, induit par l'héparine est dû à une action directe.

Zusammenfassung

Junge Katzen, intakte erwachsene Katzen und Katzen, bei welchen die Thyreoidea oder die Parathyreoidea oder beide Drüsen entfernt worden waren, erhielten Heparin. Während zwei oder mehr Monaten stiegen die Serumcalcium-Werte bei allen Tieren an. Da dieses Resultat bei Tieren ohne Thyreoidea und Parathyreoidea und bei Tieren, die die Drüsen noch hatten, beobachtet werden konnte, kann angenommen werden, daß die Calcium-mobilisierende Wirkung des Heparins eine direkte war.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Goldhaber, P.: Heparin enhancement of factors stimulating bone resorption in tissue culture. Science147, 407–408 (1965).PubMedGoogle Scholar
  2. 2.
    Gomori, G.: A modification of the colorimetric phosphorus determination for use with the photoelectric colorimeter. J. Lab. clin. Med.27, 955–960 (1942).Google Scholar
  3. 3.
    Griffith, G. C., Nichols, G., Jr., Asher, J. D., Flanagan, B.: Heparin osteoporosis. J. Amer. med. Ass.193, 91–94 (1965).Google Scholar
  4. 4.
    Jaffe, M. D., Willis, P. W. III: Multiple fractures associated with long-term sodium heparin therapy. J. Amer. med. Ass.193, 158–160 (1965).Google Scholar
  5. 5.
    Johnstone, J. M.: The appearance and significance of tissue mast cells in human bone marrow. J. clin. Path.7, 275–279 (1954).PubMedGoogle Scholar
  6. 6.
    Jones, J. D., McGuckin, W. F.: Complexometric titration of calcium and magnesium by a semiautomated procedure. Clin. Chem.10, 767–780 (1964).PubMedGoogle Scholar
  7. 7.
    Jowsey, J.: Quantitative microradiography: A new approach in the evaluation of metabolic bone disease. (Editorial.) Amer. J. Med.40, 485–491 (1966).CrossRefGoogle Scholar
  8. 8.
    Ohlwiler, D. A., Jurkiewicz, M. J., Butcher, H. R., Jr., Brown, J. B.: The effect of heparin and ascorbic acid upon the formation of collagen. Surg. Forum10, 301–303 (1959).Google Scholar
  9. 9.
    Riley, J. F.: Heparin, histamine and mast cells. (Editorial.) Blood9, 1123–1126 (1954).PubMedGoogle Scholar
  10. 10.
    Stinchfield, F. E., Sankaran, B., Samilson, R.: The effect of anticoagulant therapy on bone repair. J. Bone Jt Surg. (Amer.)38, 270–282 (1956).Google Scholar
  11. 11.
    Tourtellotte, C. D., Dziewiatkowski, D. D.: A disorder of endochrondral ossification induced by dextran sulphate. J. Bone Jt Surg. (Amer.)47, 1185–1202 (1965).Google Scholar

Copyright information

© Springer-Verlag 1970

Authors and Affiliations

  • Jenifer Jowsey
    • 1
  • Peter Adams
    • 1
  • Allen P. Schlein
    • 1
  1. 1.Mayo ClinicRochesterUSA

Personalised recommendations