Abstract
Heparin was administered to kittens, to intact cats, and to cats whose thyroids, or parathyroids, or both thyroids and parathyroids had been removed. Over 2 or more months, the serum calcium levels rose in all animals. This result, occurring both in the animals lacking thyroids and parathyroids and in those still having them, suggests that the calcium mobilizing effect of heparin was a direct one.
Résumé
De l'héparine est administrée à de jeunes chats, des chats adultes entiers, des chats thyroidectomisés ou parathyroidectomisés et des chats thyroidectomisés et parathyroidectomisés. La calcémie s'est élevée chez tous les animaux pendant 2 ou plusieurs mois. Le fait que ce résultat soit obtenu chez des animaux privés ou en possession de leurs thyroides et parathyroides, indique que l'effet de mobilisation du calcium, induit par l'héparine est dû à une action directe.
Zusammenfassung
Junge Katzen, intakte erwachsene Katzen und Katzen, bei welchen die Thyreoidea oder die Parathyreoidea oder beide Drüsen entfernt worden waren, erhielten Heparin. Während zwei oder mehr Monaten stiegen die Serumcalcium-Werte bei allen Tieren an. Da dieses Resultat bei Tieren ohne Thyreoidea und Parathyreoidea und bei Tieren, die die Drüsen noch hatten, beobachtet werden konnte, kann angenommen werden, daß die Calcium-mobilisierende Wirkung des Heparins eine direkte war.
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Mayo Clinic and Mayo Foundation: Section of Orthopedic Research (Dr. Jowsey) and Research Assistant (Dr. Adams). Mayo Graduate School of Medicine (University of Minnesota), Rochester: Resident in Orthopedic Surgery (Dr. Schlein). This investigation was supported in part by Research Grant AM-8658 from the National Institutes of Health, Public Health Service. Dr. Adams was the recipient of Research Travel Awards from the Wellcome Trust, London, and The Morgan-Williams Bequest, Welsh National School of Medicine, Cardiff, Wales.
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Jowsey, J., Adams, P. & Schlein, A.P. Calcium metabolism in response to heparin administration. Calc. Tis Res. 6, 249–253 (1970). https://doi.org/10.1007/BF02196205
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DOI: https://doi.org/10.1007/BF02196205