Abstract
Increases in plasma calcium levels caused by the infusion of calcium gluconate resulted in enhanced adrenocortical secretory rates in anesthetized dogs. Hypocalcemia resulting from the infusion of EDTA had no discernible effect on adrenocortical secretory rates, and hypophysectomy abolished the rise in secretory rates noted in the hypercalcemic intact animals. The mechanisms by which calcium may effect adrenocortical secretion are discussed with respect to its effect at various sites in the hypothalamo-hypophyseal-adrenocortical system.
Résumé
Les augmentations en teneur du calcium plasmatique, provoquées par le gluconate de calcium, donnent des taux de sécrétions plus élevées du cortex surrénalien chez les chiens anesthésiés. L'hypocalcémie consécutive à l'action du EDTA n'a pas d'action sur ces sécrétions et l'hypophysectomie supprime l'augmentation des taux de sécrétion, observés chez l'animal entier hypercalcémique. Les mécanismes par lesquels le calcium peut affecter les sécrétions cortico-surrénaliennes sont envisagés en fonction des effects au niveau des différentes phases du système hypothalamo-hypophyso-cortico-surrénalien.
Zusammenfassung
Durch Infusion von Calciumgluconat verursachte Erhöhungen des Plasmacalciumspiegels ergaben beim anaesthesierten Hund eine gesteigerte adrenocorticale Sekretion. Die Hypocalcämie, die auf Grund von EDTA-Infusion entstand, hatte keine sichtbare Wirkung auf das Ausmaß der adrenocorticalen Sekretion. Durch Hypophysektomie wurde die gesteigerte Sekretion, wie man sie beim hypercalcaemischen Tier findet, aufgehoben. Die Mechanismen, durch welche Calcium die adrenocorticale Sekretion beeinflussen kann, werden im Hinblick auf seine Wirkung an verschiedenen Stellen im hypothalamo-hypophysär-adrenocorticalen System besprochen.
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Supported in part by internal grants of the University of Illinois at the Medical Center, and the Office of Naval Research Contract NR 101-580.
Predoctoral trainee (PHS GM 738).
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Marotta, S.F., Lau, C. Effect of acute changes in plasma calcium on adrenocortical secretory rates. Calc. Tis Res. 6, 220–226 (1970). https://doi.org/10.1007/BF02196202
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DOI: https://doi.org/10.1007/BF02196202