Ventricle size and P300 in schizophrenia

  • Georg Juckel
  • Friedel M. Reischies
  • Antje Müller-Schubert
  • Anne-Cathrin Vogel
  • Wolfgang Gaebel
  • Ulrich Hegerl
Short Communication

Summary

Both ventricular enlargement and reduced P3 amplitudes are consistent findings in schizophrenic patients, suggesting that the two measures reflect a common underlying pathophysiological process in schizophrenia. Investigating 14 stabilized schizophrenic outpatients, a relationship between the size of the lateral ventricles as well as of the third ventricle on CT scans and the auditory event-related P3 amplitude was, however, not found. This negative result suggests that ventricular enlargement and reduced P3 amplitudes in schizophrenics reflect different pathophysiological processes. It is assumed that the P3 amplitude is related rather to abnormalities in the temporal lobe of schizophrenic patients.

Key words

Ventricle brain ratio Cranial computed tomography Auditory event-related potentials P300 Schizophrenia 

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References

  1. Akbarian S, Vinuela A, Kim JJ, Potkin SG, Bunney WE, Jones EG (1993) Distorted distribution of nicotinamide-adenine dinucleotide phosphate-diaphorase neurons in temporal lobe of schizophrenics implies anomalous cortical development. Arch Gen Psychiatry 50:178–187Google Scholar
  2. Arnold SE, Hyman BT, Van Hoesen GW, Damasio AR (1991) Some cytoarchitectural abnormalities of the entorhinal cortex in schizophrenia. Arch Gen Psychiatry 48:625–632Google Scholar
  3. Blackwood DHR, Young AH, McQueen JK, Martin MJ, Roxborough HM, Muir WJ, St Clair DM, Kean DM (1991) Magnetic resonance imaging in schizophrenia: altered brain morphology associated with P300 abnormalities and eye tracking dysfunction. Biol Psychiatry 30:753–769Google Scholar
  4. Cannon TD, Mednick SA, Parnas J (1989) Genetic and perinatal determinants of structural brain deficits in schizophrenia. Arch Gen Psychiatry 46:883–889Google Scholar
  5. Cohen R (1990) Event-related potentials and cognitive dysfunction in schizophrenia. In: Häfner H, Gattaz WF (eds) Search for the causes of schizophrenia, vol 2. Springer, Berlin Heidelberg New York, pp 342–360Google Scholar
  6. Conrad AJ, Abebe T, Austin R, Forsythe S, Scheibel AB (1991) Hippocampal pyramid cell disarray in schizophrenia as a bilateral phenomenon. Arch Gen Psychiatry 48:413–417Google Scholar
  7. DeLisi LE, Goldin LR, Hamovit JR, Maxwell E, Kurtz D, Gershon ES (1986) A family study of the association of increased ventricular size with schizophrenia. Arch Gen Psychiatry 43:148–153Google Scholar
  8. DeLisi LE, Stritzke P, Riordan H, Holan V, Boccio A, Kushner M, McClelland J, Van Eyl O, Anand A (1992) The timing of brain morphological changes in schizophrenia and their relationship to clinical outcome. Biol Psychiatry 31:241–254Google Scholar
  9. Gattaz WF, Kohlmeyer K, Gasser T (1990) Computer tomographic studies in schizophrenia. In: Häfner H, Gattaz WF (eds) Search for the causes of schizophrenia, vol 2. Springer, Berlin Heidelberg New York, pp 242–256Google Scholar
  10. Halgren E, Stapleton JM, Smith M, Altafullah I (1986) Generators of the human scalp P3(s). In: Cracco RQ, Bodis-Wollner I (eds) Evoked potentials. Liss, New York, pp 269–284Google Scholar
  11. Johnson R Jr (1993) On the neural generators of the P300 component of the event-related potential. Psychophysiology 30:90–97Google Scholar
  12. Juckel G, Hegerl U, Müller-Schubert A, Gaebel W, Herrmann WM (1992) P300 in schizophrenic outpatients: effects of age, gender, psychopathology and neuroleptics. Neuropsychobiology 25:70Google Scholar
  13. Kelsoe JR, Cadet JL, Pickar D, Weinberger DR (1988) Quantitative neuroanatomy in schizophrenia—a controlled magnetic resonance imaging study. Arch Gen Psychiatry 45:533–541Google Scholar
  14. Knight RT (1990) Neural mechanisms of event-related potentials: evidence from human lesion studies. In: Rohrbaugh JW, Parasuraman R, Johnson R Jr (eds) Event-related brain potentialsbasic issues and applications. Oxford University Press, New York, pp 3–18Google Scholar
  15. Lewis SW (1990) Computerised tomography in schizophrenia 15 years on. Br J Psychiatry 157 [Suppl 9]:16–24Google Scholar
  16. McCarley RW, Faux SF, Shenton M, LeMay M, Cane M, Ballinger R, Duffy FH (1989) CT abnormalities in schizophrenia—a preliminary study of their correlations with P300/P200 electrophysiological features and positive/negative symptoms. Arch Gen Psychiatry 46:698–708Google Scholar
  17. McCarley RW, Shenton ME, O'Donnell BF, Faux SF, Kikinis R, Nestor PG, Jolesz FA (1993) Auditory P300 abnormalities and left posterior superior temporal gyrus volume reduction in schizophrenia. Arch Gen Psychiatry 50:190–197Google Scholar
  18. Nasrallah HA (1990) Magnetic resonance imaging of the brain: clinical and research applications in schizophrenia. In: Häfner H, Gattaz WF (eds) Search for the causes of schizophrenia, vol 2. Springer, Berlin Heidelberg New York, pp 257–274Google Scholar
  19. Pietzcker A (1985) A German multicentre study on long-term treatment of schizophrenic outpatients. Pharmacopsychiatry 18: 333–338Google Scholar
  20. Pritchard WS (1986) Cognitive event-related potential correlates of schizophrenia. Psychol Bull 100:43–66Google Scholar
  21. Raz S, Raz N (1990) Structural brain abnormalities in the major psychoses: a quantitative review of the evidence from computerised imaging. Psychol Bull 108:93–108Google Scholar
  22. Roberts GW (1991) Schizophrenia: a neuropathological perspective. Br J Psychiatry 158:8–17Google Scholar
  23. Romani A, Merello S, Gozzoli L, Zerbi F, Grassi M, Cosi V (1987) P300 and CT scan in patients with chronic schizophrenia. Br J Psychiatry 151:506–513Google Scholar
  24. Suddath RL, Casanova MF, Goldberg TE, Daniel DG, Kelsoe JR, Weinberger DR (1989) Temporal lobe pathology in schizophrenia: a quantitative magnetic resonance imaging study. Am J Psychiatry 146:464–472Google Scholar
  25. Van Horn JD, McManus IC (1992) Ventricular enlargement in schizophrenia—a meta-analysis of studies of the ventricle brain ratio (VBR). Br J Psychiatry 160:687–697Google Scholar

Copyright information

© Springer-Verlag 1994

Authors and Affiliations

  • Georg Juckel
    • 1
  • Friedel M. Reischies
    • 1
  • Antje Müller-Schubert
    • 1
  • Anne-Cathrin Vogel
    • 1
  • Wolfgang Gaebel
    • 1
  • Ulrich Hegerl
    • 1
  1. 1.Laboratory of Clinical Psychophysiology, Department of PsychiatryFreie Universität BerlinBerlinGermany

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