Factors associated with low cognitive performance in general practice

  • Marie-José Dealberto
  • Bruno Sauron
  • Christian Derouesné
  • Patrice Boyer
  • Daniel Mayeux
  • François Piette
  • François Kohler
  • Serge Lubin
  • Annick Alpérovitch
Original Paper


In the preparatory phase of a randomised controlled trial data were collected to assess the magnitude of changes on cognitive functions in 1628 volunteers (age range 45–75 years) that were recruited from general practitioners' patient population. Subjects were administered a short neuropsychological battery of tests including three paper-and-pencil tests, which assessed immediate recall, delayed memory, and attention. Being on antihypertensive medication was associated with low results for all three tests in every age group, and in all strata according to blood pressure levels. Psychotropic drug use was correlated with low results for all three tests. Differences between psychotropic drug users and nonusers increased with age. Antihypertensive treatment and psychotropic drug use seem to be important to consider in longitudinal studies of cognitive decline in aging.

Key words

Ageing Cognitive functioning Hypertension Psychotropic drug use 


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Copyright information

© Springer-Verlag 1994

Authors and Affiliations

  • Marie-José Dealberto
    • 1
  • Bruno Sauron
    • 2
  • Christian Derouesné
    • 3
  • Patrice Boyer
    • 4
  • Daniel Mayeux
    • 5
  • François Piette
    • 6
  • François Kohler
    • 5
  • Serge Lubin
    • 7
  • Annick Alpérovitch
    • 1
  1. 1.Unit 360Institut National de la Santé et de la Recherche Médicale (INSERM)Villejuif, CedexFrance
  2. 2.Hôpital Saint-MichelParisFrance
  3. 3.Centre Hospitalier Pitié-SalpêtrièreParisFrance
  4. 4.INSERM Hôpital Sainte-AnneParisFrance
  5. 5.Laboratoire de Santé Publique et d'Informatique MédicaleNancyFrance
  6. 6.Hôpital Charles FoixIvryFrance
  7. 7.Hôpital DupuytrenDraveilFrance

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