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Avoidance behaviour in the rat after 5-hydroxytryptophan (5-HTP) administration

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Résumé

L'effet de l'administration du 5-HTP, en doses peu élevées, a été étudié par une méthode utilisant la cage deSkinner: un stimulus auditif annonce l'arrivée d'un choc électrique dans un délai de 9 secondes à moins que l'animal ne presse une barre située dans la paroi de la cage.

Le temps de réaction entre le stimulus conditioné et la réponse conditionée est augmenté après l'administration du 5-HTP et le nombre de chocs reçus par le rat augmente suivant la dose. Les résultats suggèrent que le 5-HTP exerce une action dépressive sous les conditions de cette expérience.

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Authors and Affiliations

  1. Department of Psychology, Birkbeck College, Malet Street, London, W.C. 1, Great Britain

    Daphné Joyce & H. M. B. Hurwitz

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  1. Daphné Joyce
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  2. H. M. B. Hurwitz
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Additional information

The experiments reported in this paper were conducted under a Medical Research Council grant toH. M. B. Hurwitz and the production of the paper was supported in part by research grant MH-03313 from the National Institute of Mental Health, U.S. Public Health Service.

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Joyce, D., Hurwitz, H.M.B. Avoidance behaviour in the rat after 5-hydroxytryptophan (5-HTP) administration. Psychopharmacologia 5, 424–430 (1964). https://doi.org/10.1007/BF02193479

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  • DOI: https://doi.org/10.1007/BF02193479

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