The effect of particle size of disintegrants on the disintegration of tablets
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The effect has been studied of particle size of disintegrants on the disintegration time of tablets, compressed without a lubricant and after mixing the ingredients with magnesium stearate, respectively. The results show for the tablets containing a slightly swelling disintegrant, like potato and rice starch, a decreasing negative effect of mixing with magnesium stearate on the disintegration time of the tablets with decreasing particle size of disintegrant. Only a slight effect of particle size and of mixing time with magnesium stearate on the disintegration of the tablets is found for the tablets containing a strongly swelling disintegrant, like sodium starch glycolate.
KeywordsStarch Potato Starch Disintegration Time Magnesium Stearate Rice Starch
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- Bolhuis, G.K., C.F. Lerk, H.T. Zijlstra andA.H. De Boer (1975)Pharm. Weekblad 110, 317–325.Google Scholar
- Bolhuis, G.K., A.J. Smallenbroek andC.F. Lerk (1981)J. Pharm. Sci., accepted for publication.Google Scholar
- Dees, P.J. (1980) Ph.D. thesis, Leiden, The Netherlands.Google Scholar
- List, P.H., andU.A. Muazzam (1979)Pharm. Ind. 41, 1075–1077.Google Scholar