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Pharmaceutisch weekblad

, Volume 3, Issue 1, pp 1048–1051 | Cite as

The effect of particle size of disintegrants on the disintegration of tablets

  • A. J. Smallenbroek
  • G. K. Bolhuis
  • C. F. Lerk
Article

Abstract

The effect has been studied of particle size of disintegrants on the disintegration time of tablets, compressed without a lubricant and after mixing the ingredients with magnesium stearate, respectively. The results show for the tablets containing a slightly swelling disintegrant, like potato and rice starch, a decreasing negative effect of mixing with magnesium stearate on the disintegration time of the tablets with decreasing particle size of disintegrant. Only a slight effect of particle size and of mixing time with magnesium stearate on the disintegration of the tablets is found for the tablets containing a strongly swelling disintegrant, like sodium starch glycolate.

Keywords

Starch Potato Starch Disintegration Time Magnesium Stearate Rice Starch 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Bohn, Scheltema & Holkema 1981

Authors and Affiliations

  • A. J. Smallenbroek
    • 1
  • G. K. Bolhuis
    • 1
  • C. F. Lerk
    • 1
  1. 1.Laboratory for Pharmaceutical Technology and DispensingState UniversityAW GroningenThe Netherlands

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