Multiple dopamine receptors: fact, fiction or confusion?

Abstract

A critical review of the various theories postulating the existence of multiple dopamine (DA) receptors is presented. After a summary of the pharmacological methods used in measuring dopaminergic agonist and antagonist activities the evidence for postsynaptic, presynaptic, D-I, D-2, D-3, DA-1, DA-2, DAe and Dai receptors is examined. The possible clinical significance of these various theories is also briefly discussed.

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In honour of ProfessorHuizinga on the occasion of his retirement.

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Horn, A.S., Feenstra, M.G.P., Grol, C.J. et al. Multiple dopamine receptors: fact, fiction or confusion?. Pharmaceutisch Weekblad Scientific Edition 3, 1021–1041 (1981). https://doi.org/10.1007/BF02193319

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Keywords

  • Substantia Nigra
  • Adenylate Cyclase
  • Apomorphine
  • Sulpiride
  • Kainic Acid