The effect of 2,4,6-triaminopyrimidine on increased mucosal permeability of guinea-pig colonic mucosa, following administration of 1,8-dihydroxyanthraquinone, salicylic acid and dinitrophenol

Abstract

Administration of 1,8-dihydroxyanthraquinone to guinea-pigs increases colonic permeability. The transfer of99mTc-labelled EDTA from mucosa to serosa was markedly increasedin vivo. In one hour 25% of the administered radioactive compound leaked out of the colon to concentrate in the urine. A similar enhanced complex transfer was observed following administration of salicylic acid and dinitrophenol (DNP), respectively 14% and 12%. The increased permeability could be restored to nearly normal values after 2,4,6-triaminopyrimidine (TAP) injection in the colon segment.

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Verhaeren, E.H.C., Verbruggen, A.M. & Lemli, J.A.J.M. The effect of 2,4,6-triaminopyrimidine on increased mucosal permeability of guinea-pig colonic mucosa, following administration of 1,8-dihydroxyanthraquinone, salicylic acid and dinitrophenol. Pharmaceutisch Weekblad Scientific Edition 3, 815–819 (1981). https://doi.org/10.1007/BF02193278

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Keywords

  • Salicylic Acid
  • Anthraquinone
  • Dinitrophenol
  • Colon Segment
  • Methyl Ethyl Ketone