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Pflügers Archiv

, Volume 431, Issue 4, pp 527–532 | Cite as

Components of energy expenditure in themdx mouse model of Duchenne muscular dystrophy

  • A. Mokhtarian
  • A. Decrouy
  • A. Chinet
  • P. C. Even
Original Article

Abstract

Previous observations showing that basal heat production rates and glucose metabolism were reduced inmdx mouse skeletal muscles incubated in vitro led us to study the components of total energy expenditure by open-circuit indirect calorimetry in the intact, free-movingmdx mouse. Our purpose was to verify if themdx mouse exhibited whole-body alterations in energy metabolism. The results revealed that total and basal energy expenditure, as well as spontaneous activity, energetic cost of activity, and, therefore, energy expended in relation to activity were not significantly different in C57B1 / 10 (control) and in dystrophic (mdx) mice. In contrast, the thermic effect of food was 32% larger inmdx than in control mice and was accompanied by significant differences in postprandial glucose and lipid oxidation. The present in vivo study could not show a direct demonstration that impaired glucose metabolism by skeletal muscles participated in this phenomenon. However, since postprandial glucose metabolism by skeletal muscles contributes a significant part of the thermic effect of food, the present data are in line with previous studies in vitro that show thatmdx mouse skeletal muscles probably suffer an impaired control of their energy metabolism.

Key words

mdx mouse Duchenne muscular dystrophy Whole-body indirect calorimetry Thermic effect of food Spontaneous activity Energy metabolism Glucose metabolism 

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Copyright information

© Springer-Verlag 1996

Authors and Affiliations

  • A. Mokhtarian
    • 1
  • A. Decrouy
    • 2
  • A. Chinet
    • 2
  • P. C. Even
    • 1
  1. 1.Laboratoire de Neurobiologie des RégulationsCNRS URA 1860, College de FranceParis Cedex 05France
  2. 2.Département de PhysiologieCentre Médical Universitaire, Faculté de MédecineGeneve 4Switzerland

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