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A fission yeast gene mapping close tosuc1 encodes a protein containing two bromodomains

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Abstract

A novel gene,brd1, has been cloned from the fission yeastSchizosaccharomyces pombe. The predictedbrd1 product contains two copies of an imperfect repeat of 96 amino acid residues in its N-terminal half. These each include a region with high homology to the bromodomains found in transcriptional activator proteins from a diversity of eukaryotes. An in vivo deletion of the completebrd1 open reading frame is not lethal but cells exhibit thermosensitivity, with reductions in both cell growth and stationary phase survival at 36°C.brd1 maps adjacent to the genesuc1, but is expressed separately to give a low abundance 2.1 kb mRNA.

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Author notes

  1. Geraldine A. Phear

    Present address: Department of Radiology, Eccles Institute of Human Genetics, University of Utah, 84102, Salt Lake City, Utah, USA

Authors and Affiliations

  1. Department of Biological Sciences, University of Exeter, Washington Singer Laboratories, Perry Road, EX44QG, Exeter, UK

    Stephen J. Aves & Nicholas Tongue

  2. Department of Biochemistry, University of Bristol, University Walk, BS8 1TD, Bristol, UK

    John Hindley & Geraldine A. Phear

Authors
  1. Stephen J. Aves
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  2. John Hindley
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  3. Geraldine A. Phear
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  4. Nicholas Tongue
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Communicated by B. J. Kilbey

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Aves, S.J., Hindley, J., Phear, G.A. et al. A fission yeast gene mapping close tosuc1 encodes a protein containing two bromodomains. Molec. Gen. Genet. 248, 491–498 (1995). https://doi.org/10.1007/BF02191650

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  • DOI: https://doi.org/10.1007/BF02191650

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