Summary
The prevalence of the apolipoprotein E-4 allele (ApoE-4) was significantly higher in a referral population of 40 patients with clinically diagnosed Alzheimer's disease than in a sample of non-demented elderly controls (P<0.01). The highest plasma cholesterol levels were found in demented patients homozygotic for Apo E-4, but no significant increases of glucose, triglycerides and thyroxine or of leuko-araiosis and brain infarcts were verified in this preliminary study.
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Czech, C., Förstl, H., Hentschel, F. et al. Apolipoprotein E-4 gene dose in clinically diagnosed Alzheimer's disease: prevalence, plasma cholesterol levels and cerebrovascular change. Eur Arch Psychiatry Clin Nuerosci 243, 291–292 (1994). https://doi.org/10.1007/BF02191587
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DOI: https://doi.org/10.1007/BF02191587