Marchiafava-Bignami disease. A case studied by structural and functional brain imaging

  • T. Humbert
  • P. De Guilhermier
  • C. Maktouf
  • G. Grasset
  • F. M. Lopez
  • P. Chabrand
Original Articles


Marchiafava-Bignami disease (MBD) is a rare complication of chronic alcoholism. The clinical features, X-ray, CT and MRI findings are well documented. However, functional brain imaging has not been used in cases of MBD. We used single-photon emission computed tomography (SPECT) to monitor the regional cerebral blood flow in a patient suffering from a acute form of MBD, from which he subsequently recovered. Several abnormalities were found. A more frequent use of functional brain imaging in MBD could improve our knowledge of pathogenesis and prognosis for MBD.

Key words

Marchiafava-Bignami disease CT MRI SPECT Corpus callosum 


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Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • T. Humbert
    • 1
  • P. De Guilhermier
    • 2
  • C. Maktouf
    • 3
  • G. Grasset
    • 3
  • F. M. Lopez
    • 2
  • P. Chabrand
    • 1
  1. 1.Service de Psychiatrie B1Hôpital Gaston Doumergue, C.H.U.NimesFrance
  2. 2.Département d'Imagerie MédicaleHôpital Gaston Doumergue, C.H.U.NimesFrance
  3. 3.Service Central de Médecine Nucléaire et de Biophysique MédicaleHôpital Gaston Doumergue, C.H.U.NimesFrance

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