Abstract
To evaluate the prognostic significance of the age at onset of chronicPseudomonas aeruginosa colonization (OPCP) with respect to pulmonary disease progression in patients with cystic fibrosis (CF), a retrospective long-term analysis using annual chest radiographs was performed on 54 CF patients. Thirtyseven patients (68%) were chronically colonized before the age of 12 years (group 1), 17 patients (32%) thereafter (group 2). These two groups did not significantly differ in terms of mean duration of follow up (16.2±5.9 years), sex, CF genotypes, colonization with other respiratory pathogens, supportive medical treatment and death rate during the study period. Chest radiographs were evaluated according to the Chrispin-Norman score, increasing scores representing increasing severity of respiratory disease. In both groups, progression of score means was not accelerated up to 6 years after OCPC (Scores at OCPC set 0; mean score ±SEM 6 years prior to OCPC −5.6±2.0; 10 years after OCPC +3.6±0.7 points). Patients chronically colonized prior to age 12 years (group 1) scored significantly higher between age 2 and 11 years (maximum difference at age 8 years [mean ±SEM]: 9.4±0.7 vs. 4.3±1.3 points;P= 0.002) as compared to group 2. After age 11 years, mean scores were similar in both groups, since in group 2 scores increased rapidly after age 8 years. We conclude that OCPC did not cause an immediate acceleration of CF lung disease judged by serial chest radiographs. Rapid progression in group 2 (OCPC after age 12 years) was independent of OCPC since it occurred earlier. These data indicate that OCPC may be a marker rather than the cause of respiratory disease progression.
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Abbreviations
- CF :
-
cystic fibrosis
- OCPC :
-
onset of chronic
- Pseudomonas aeruginosa :
-
colonization
- PA :
-
Pseudomonas aeruginosa
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Aebi, C., Bracher, R., Liechti-Gallati, S. et al. The age at onset of chronicPseudomonas aeruginosa colonization in cystic fibrosis —prognostic significance. Eur J Pediatr 154 (Suppl 4), S69–S73 (1995). https://doi.org/10.1007/BF02191510
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DOI: https://doi.org/10.1007/BF02191510