Summary
The growth hormone (GH) and cortisol responses to intravenous clonidine (0.15mg) treatment of 25 melancholic patients, 12 with and 13 without delusions, were studied with placebo control. The baseline concentrations of the main noradrenaline metabolite, 3-methoxy-4-hydroxyphenylglycol (MHPG) were also estimated in urine. Cortisol plasma levels decreased significantly and equally after both placebo and clonidine. Baseline cortisol levels correlated positively with urinary MHPG. Clonidine did not increase GH levels significantly over time compared with placebo. Delusional melancholic patients tended to have smaller GH responses to clonidine than nondelusionals (F=2.18,P=0.06). There were no differences in GH response to clonidine between high and low MHPG excretors.
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Aberg-Wistedt A, Wistedt B, Bertlisson L (1985) Higher CSF levels of HVA and 5-HIAA in delusional compared to nondelusional depression. Arch Gen Psychiatry 42:925–926
Amsterdam JD, Maislin G, Skolnick B, Berwish N, Winokur A (1989) Multiple hormone response to clonidine administration in depressed patients and healthy volunteers. Biol Psychiatry 26:265–278
Brambilla F, Lambertico M, Sali L, Caragnini CI, Invitti C, Maggioni M, Candolfi C, Panerai AE, Muller EC (1987) Clonidine stimulation in anorexia nervosa: growth hormone, cortisol and beta-endorphin responses. Psychiatry Res 20:19–31
Charney DS, Heninger GR, Sternberg DE, Hafstad KM, Giddings S, Landis DH (1982) Adrenergic receptor sensitivity in depression: effects of clonidine in depressed patients and healthy subjects. Arch Gen Psychiatry 39:290–294
Checkley SA (1980) Neuroendocrine tests of monoamine function in man: a review of basic theory and its application to the study of depressive illness. Psychol Med 10:35–53
Checkley SA, Slade AP, Shur E (1981) Growth hormone and other responses to clonidine in patients with endogenous depression. Br J Psychiatry 138:51–55
Checkley SA, Glass IB, Thomson C, Corn T, Robinson P (1984) The GH response to clonidine in endogenous as compared with reactive depression. Psychol Med 14:773–774
Corn T, Checkley SA, Thompson C (1984) Effects of desipramine upon central adrenoreceptor function in normal subjects. Br J Psychiatry 145:139–145
Fernstrom JD (1976) The effect of nutritional factors on brain aminoacid levels and monoamine synthesis. Fed Proc 35:1151–1156
Hamilton M (1960) A rating scale for depression. J Neurol Neurosurg Psychiatry 23:56–62
Harris J, Krohenbuhl CS, Malchow RD (1985) Neurochemistry of stress: urinary biogenic amine metabolite excretion rates in exercise. Biogen Amines 2:261–267
Hoehe M, Valido G, Matussek N (1988) Growth hormone, noradrenaline, blood pressure and cortisol responses to clonidine in healthy male volunteers: dose-response relations and reproducibility. Psychoneuroendocrinology 13:408–418
Hunt GE, O'Sullivan BT, Johnson GFS, Smythe GA (1986) Growth hormone and cortisol secretion after oral clonidine in healthy adults. Psychoneuroendocrinology 11:317–325
Jimerson DC, Insel TR, Reus VI, Kopin IJ (1983) Increased plasma MHPG in dexamethasone resistant depressed patients. Arch Gen Psychiatry 40:173–176
Lal S, Tolis G, Martin JB, Brown GM, Guyda H (1975) Effect of clonidine on growth hormone prolactin, luteinizing hormone, follicle-stimulating hormone, and thyroid-stimulating hormone in the serum of normal men. J Clin Endocrinol Metab 41:827–832
Lykouras E, Markianos M, Malliaras D, Stefanis C (1988) Neurochemical variables in delusional depression. Am J Psychiatry 145:214–217
Matussek N, Ackenheil M, Hippius H, Müller F, Schröder H-T, Schultes H, Wasilewski B (1980) Effect of clonidine on growth hormone release in psychiatric patients and controls. Psychiatry Res 2:25–36
Roose SP, Glassman AH (1988) Delusional depression. In: Georgotas A, Cancro R (eds) Depression and mania. Elsevier, New York, pp 76–85
Rosenbaum AH, Maruta T, Schatzberg AF, Orsulak PJ, Jiang N-S, Cole JO, Schildkraut JJ (1983) Toward a biochemical classification of depressive disorders. VII. Urinary free cortisol and urinary MHPG in depressions. Am J Psychiatry 140:314–318
Sachar EJ, Hellman L, Roffwarg HP, Halpern FS, Fukushima DK, Gallagher TF (1973) Disrupted 24-hour patterns of cortisol secretion in psychotic depression. Arch Gen Psychiatry 28:19–24
Schittecatte M, Charles G, Machowski R, Wilmotte J (1989) Tricyclic wash-out and growth hormone response to clonidine. Br J Psychiatry 154:858–863
Siever LJ, Uhde TW (1984) New studies and perspectives on the noradrenergic receptor system in depression: effects of the ±2-adrenergic agonist clonidine. Biol Psychiatry 19:131–155
Siever LJ, Uhde TW, Jimerson DC, Post RM, Lake R, Murphy DL (1984) Plasma cortisol responses to clonidine in depressed patients and controls. Evidence for a possible alteration in noradrenergic-neuroendocrine relationships. Arch Gen Psychiatry 41:63–68
Stokes PE, Frazer A, Casper R (1981) Unexpected neuroendocrine-transmitter relationships. Psychopharmacol Bull 17:72–75
Sweeney D, Nelson C, Bowers M, Maas J, Heninger G (1978) Delusional versus non-delusional depression: neurochemical variables. Lancet 2:100–101
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Lykouras, L., Markianos, M., Hatzimanolis, J. et al. Hormonal responses to clonidine and urinary MHPG in delusional and nondelusional melancholic patients: a placebo-controlled study. Eur Arch Psychiatry Clin Nuerosci 241, 77–81 (1991). https://doi.org/10.1007/BF02191144
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DOI: https://doi.org/10.1007/BF02191144