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σs-dependent overexpression offtsZ in anEscherichia coli K-12 rpoB mutant that is resistant to the division inhibitors DicB and DicF RNA

Molecular and General Genetics MGG volume 248, pages 190–194 (1995)Cite this article

Abstract

TheEscherichia coli genesdicF anddicB encode division inhibitors, which prevent the synthesis and activity, respectively, of the essential division protein FtsZ. A mutation at the C-terminal end of the RNA polymeraseβ subunit renders cells resistant to both inhibitors. In the mutant strain the level of theftsZ gene product is higher than in the wild type. Disruption ofrpoS, which encodes the stationary phase sigma factor σS, lowers FtsZ protein levels in the mutant, and partially restores sensitivity to the inhibitors.

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Affiliations

  1. Laboratoire de Microbiologie et Génétique moléculaire Centre National de la Recherche Scientifique, 118 Route de Narbonne, 31062, Toulouse, France

    Kaymeuang Cam, Alain Cuzange & Jean-Pierre Bouché

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  1. Kaymeuang Cam
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  2. Alain Cuzange
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  3. Jean-Pierre Bouché
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Communicated by J. F. Hengler

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Cam, K., Cuzange, A. & Bouché, JP. σs-dependent overexpression offtsZ in anEscherichia coli K-12 rpoB mutant that is resistant to the division inhibitors DicB and DicF RNA. Molec. Gen. Genet. 248, 190–194 (1995). https://doi.org/10.1007/BF02190800

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  • DOI: https://doi.org/10.1007/BF02190800

Key words

  • Escherichia coli K-12
  • rpoB
  • ftsZ
  • rpoS
  • Cell division