Abstract
Using a randomized double blind study design, the bronchodilating effect of 200 µg inhaled oxitropium bromide (OB) was compared with 200 µg inhaled fenoterol (F) after an interval of 20 min, in 20 asthmatic children aged 12.7 years (range: 4.9–15.1 years), suffering from mild bronchoconstriction (mean forced expiratory volume during ls: 73.4%, range: 51%–85%). Both drugs induced a comparable degree of bronchodilatation and no significant differences were found between the OB group and the F group, suggesting equipotency for both drugs after a 20 min interval, at the 200 µg dose level. Furthermore, a significant improvement of lung function parameters was detected in both groups after subsequent administration of 400 µg F, indicating that inhalation of 200 µg of OB or F results in submaximal bronchodilation in asthmatic children suffering from mild bronchoconstriction.
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Abbreviations
- F :
-
fenoterol
- FEW :
-
forced expiratory volume during ls
- MEF25 :
-
maximal expiratory flow at 25% of VC
- MEF50 :
-
maximal expiratory flow at 50% of VC
- OB :
-
oxitropium bromide
- VC :
-
vital capacity
References
American Thoracic Society (1962) Definitions and classification of chronic bronchitis, asthma and pulmonary emphysema. Am Rev Respir Dis 85: 762–768
Frith PA, Jenner B, Dangerfield R, Atkinson J, Drennam C (1986) Oxytropium bromide. Dose-response and time-response study of a new anticholinergic bronchodilator drug. Chest 86: 249–253
Higgings BG, Powell RM, Cooper S, Tattersfield AE (1991) Effect of salbutamol and ipratropium bromide on airway calibre and bronchial reactivity in asthma and chronic bronchitis. Eur Respir J 4: 415–420
Joppich R (1987) Vergleich der Wirkungen von Reproterol, Oxitropiumbromid, DNCG und Theophyllin auf das Anstrengungs-Asthma bei kindern. Atemwegs Lungenkr 13: 453–456
Neijens HJ, Wesselius TR, Kerrebijn KF (1981) Farmacologische beïnvloeding van kortademigheid door inspanning bij kinderen met CARA. Ned T Geneesk 32: 1277–1281
Neijens HJ, Wesselius TR, Kerrebijn KF (1981) Exercise-induced bronchoconstriction as an expression of bronchial hyperreactivity: a study of its mechanisms in children. Thorax 36: 517–522
Neijens HJ, Gargani G, Van Kralingen A, Van Weezepoel N, Kerrebijn KF (1982) Central versus peripheral airway obstruction in bronchial responsiveness due to exercise. Eur J Respir Dis 63 [Suppl 121]: 105–112
Nolte D (1978) Double-blind crossover comparison between a beta-adrenergic agent and a new anticholinergic agent by metered dose inhaler. Respiration 36: 32–38
Peel ET, Anderson G (1984) A dose-response study of oxitropium bromide in chronic bronchitis. Thorax 39: 453–456
Pounsford JC, Fuller RW, Saunders KB (1983) A cumulative dose response study of oxitropium bromide (Ba 253) in asthmatics. Eur J Respir Dis 64 [Suppl 128]: 536–539
Skorodin MS, Gross NJ, Moritz T, King FW, Armstrong W, Wells D, Galavan E, Slutsky L (1986) Oxitropium bromide, a new anticholinergic bronchodilator. Ann Allergy 56: 229–232
Wilson NM, Green S, Coe C, Barnes PJ (1987) Duration of protection by oxitropium bromide against cholinergic challenge. Eur J Respir Dis 71: 455–458
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Van Bever, H.P., Desager, K.N., Pauwels, J.H. et al. Comparison of the bronchodilating effect of oxitropium bromide and fenoterol in asthmatic children. Eur J Pediatr 153, 604–606 (1994). https://doi.org/10.1007/BF02190670
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DOI: https://doi.org/10.1007/BF02190670