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The interaction of the Bainbridge and Bezold-Jarisch reflexes in the conscious dog

Basic Research in Cardiology volume 86, pages 175–185 (1991)Cite this article

Summary

Experiments were undertaken to determine the efferent path of the Bainbridge reflex and to investigate the interaction of the Bainbridge reflex with the Bezold-Jarisch reflex in conscious, chronically instrumented dogs. The Bainbridge reflex was elicited by distending the left atrium by inflating a chronically implanted balloon catheter. The Bezold-Jarisch reflex was elicited using chemical stimulation of left ventricular receptors with infusions of veratridine (0.1–0.8 μg/kg/min) into the left circumflex coronary artery. Heart-rate responses to left atrial balloon inflation were compared before and after either β-1 antagonism with metoprolol or cholinergic antagonism with atropine, and before and during left ventricular receptor stimulation with intracoronary veratridine. Left atrial balloon inflation alone caused a significant increase in heart rate (70.1 ± 5 bpm), left atrial pressure (14 ± 3 mm Hg) and mean arterial blood pressure (10 ± 2 mm Hg). Heart-rate responses to left atrial distension were inhibited, but not abolished by either cholinergic or β-1 antagonism. Left atrial distension after both cholinergic and β-1 antagonism abolished the heart-rate response to balloon inflation. These results indicate that the efferent component of the Bainbridge reflex has both a vagal and a sympathetic component in conscious dogs. Left atrial distension during simultaneous left ventricular receptor stimulation resulted in a significantly decreased tachycardia than did left atrial distension alone (26 ± 3 bpm compared to 68 ± 8 bpm in the control experiments). In addition, the slope of the heart rate vs left atrial pressure relationship was significantly inhibited by left ventricular receptor stimulation (1.8 ± 0.2 bpm/mm Hg compared to 5.7 ± 0.3 bpm/mm Hg in the control experiments). There were no significant differences in either the left atrial pressure or arterial blood pressure changes between the two groups. These data suggest an interaction between these two reflexes that may be occurring in the central nervous system.

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References

  1. Bainbridge FA (1915) The influence of venous filling upon the rate of the heart. J Physiol (Lond) 50:65–84

    Google Scholar 

  2. Bezold AV, Hirt L (1867) Über die physiologischen Wirkungen des essigsauren Veratrins. Unters Physiol Lab Würzburg 1:75–156

    Google Scholar 

  3. Boettcher DH, Zimpfer M, Vatner SF (1982) Phylogenesis of the bainbridge reflex. Am J Physiol 242:R244–R246

    PubMed  Google Scholar 

  4. Coleridge JCG, Linden RJ (1955) The effect of intravenous infusions upon the heart rate of the anaesthetized dog. J Physiol (Lond) 128:310–319

    Google Scholar 

  5. Dawes GS (1947) Studies on veratrum alkaloids. J Pharmacol Exp Ther 89:325–342

    Google Scholar 

  6. Edis, AJ, Donald DE, Shepherd JT (1970) Cardiovascular reflexes from stretch of pulmonary veinatrial junctions in the dog. Circ Res 27:1091–1100

    PubMed  Google Scholar 

  7. Fater DC, Schultz HD, Sundet WD, Mapes JS, Goetz KL (1982) Effects of left atrial stretch in cardiac-denervated and intact conscious dogs. Am J Physiol 242:H1056–H1064

    PubMed  Google Scholar 

  8. Furnival CM, Linden RJ, Snow HM (1971) Reflex effects on the heart of stimulating left atrial receptors. J Physiol (Lond) 218:447–463

    Google Scholar 

  9. Goetz KL (1965) Effect of increased pressure within a right heart cul-de-sac on heart rate in dogs. Am J Physiol 209:507–512

    PubMed  Google Scholar 

  10. Herd JA, Barger AC (1964) Simplified technique for chronic catheterization of blood vessels. Journal of Applied Physiology 19:791–792

    PubMed  Google Scholar 

  11. Holmberg MJ, German AJ, Cornish KG, Zucker IH (1983) Attenuation of arterial baroreflex control of heart rate by left ventricular receptor stimulation in the conscious dog. Circ Res 52:597–607

    PubMed  Google Scholar 

  12. Holmberg MJ, Zucker IH (1986) Increased left ventricular pressure attenuates the baroreflex in unanesthetized dogs. Am J Physiol 251:H23–R31

    Google Scholar 

  13. Kappagoda CT, Linden RJ, Scott EM, Snow HM (1975) Atrial receptors and heart rate: the efferent pathway. J Physiol (Lond) 249:581–590

    Google Scholar 

  14. Kappagoda CT, Linden RJ, Snow HM (1972) A reflex increase in heart rate from distension of the junction between the superior vena cava and the right atrium. J Physiol (Lond) 220:177–197

    Google Scholar 

  15. Kappagoda CT, Linden RJ, Snow HM (1972) The effect of stretching the superior vena caval-right atrial junction on right atrial receptors in the dog. J Physiol (Lond) 227:875–887

    Google Scholar 

  16. Ledsome JR, Linden RJ (1967) The effect of distending a pouch of the left atrium on the heart rate. J Physiol (Lond) 193:121–129

    Google Scholar 

  17. Linden RJ, Kappagoda CT (1982) Atrial Receptors. Cambridge University Press, Cambridge

    Google Scholar 

  18. Mark AL (1983) The Bezold-Jarisch reflex revisited: clinical implications of inhibitory reflexes originating in the heart. J Amer Coll Cardiol 1:90–102

    Google Scholar 

  19. Mark AL, Kioschos JM, Abboud FM, Heistad DD, Schmid PG (1973) Abnormal vascular responses to exercise in patients with aortic stenosis. J Clin Invest 52:1138–1146

    PubMed  Google Scholar 

  20. Nevalainen TO, Hakumäki MOK, Hydöynmaa SJ, Närhi MV, Sarajas HSS (1980) Distension of the pulmonary vein-left atrial junction: heart rate responses in conscious and anesthetized dogs. Acta Physiol Scand 110:47–52

    PubMed  Google Scholar 

  21. Panzenbeck MJ, Tan W, Hajdu MA, Zucker IH (1988) Intracoronary infusion of prostaglandin 12 attenuates arterial baroreflex control of heart rate in conscious dogs. Circ Res 63:860–868

    PubMed  Google Scholar 

  22. Perez-Gomez F, de Dios RM, Rey J, Aguado AG (1979) Prinzmetal's angina: reflex cardiovascular response during episode of pain. Brit Heart J 42:81–87

    PubMed  Google Scholar 

  23. Teo KK, Man GCW, Kappagoda CT (1985) Interaction of left atrial receptors and carotid sinus baroreceptors on heart rate in the dog. Am J Physiol 248:H631–H636

    PubMed  Google Scholar 

  24. Thames MD, Abboud FM (1979) Reflex inhibition of renal sympathetic nerve activity during myocardial ischemia mediated by left ventricular receptors with vagal afferents in dogs. J Clin Invest 63:395–402

    PubMed  Google Scholar 

  25. Vatner SF, Braunwald E (1975) Cardiovascular control mechanisms in the conscious state. N Engl J Med 293:970–976

    PubMed  Google Scholar 

  26. Zucker IH, Cornish KG (1980) Reflex cardiovascular effects of serotonin in conscious and anesthetized dogs. Circ Res 47:509–515

    PubMed  Google Scholar 

  27. Zucker IH, Cornish KG (1981) The Bezold-Jarisch reflex in the conscious dog. Circ Res 49:940–948

    PubMed  Google Scholar 

  28. Zucker IH, German AJ, Cornish KG, Lang M (1985) Impaired atrial receptor modulation of renal nerve activity in dogs with chronic volume overload. Cardiovasc Res 19:411–418

    PubMed  Google Scholar 

  29. Zucker IH, Niebauer MJ, Cornish KG (1986) Acute aortic stenosis in the conscious dog: effects of inotropic state on heart rate. Am J Physiol 50:159–166

    Google Scholar 

  30. Zucker IH, Panzenbeck MJ, Hackley JF, Haiderzad K (1989) Baroreflex inhibition during coronary occlusions mediated by prostaglandins. Am J Physiol 257:R216–R223

    PubMed  Google Scholar 

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Author notes

  1. M. A. Hajdu

    Present address: 135ML., Dept. of Pathology, University of Iowa, 52242, Iowa City, Ia.

  2. M. J. Panzenbeck

    Present address: Dept. of Pharmacol., Boehringer Ingelheim, 175 Briar Ridge Rd., 06877, Ridgefield, Conn.

Authors and Affiliations

  1. Department of Physiology and Biophysics, The University of Nebraska College of Medicine, 600 S. 42nd St., 68198-4575, Omaha, Nebraska, USA

    M. A. Hajdu, K. G. Cornish, Wen Tan, M. J. Panzenbeck &  I. H. Zucker

Authors
  1. M. A. Hajdu
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  2. K. G. Cornish
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  3. Wen Tan
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  4. M. J. Panzenbeck
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  5. I. H. Zucker
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Additional information

Supported by funds from NIH grant HL-33359 and by a pre-doctoral fellowship from the Nebraska affiliate of the American Heart Association

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Hajdu, M.A., Cornish, K.G., Tan, W. et al. The interaction of the Bainbridge and Bezold-Jarisch reflexes in the conscious dog. Basic Res Cardiol 86, 175–185 (1991). https://doi.org/10.1007/BF02190550

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  • DOI: https://doi.org/10.1007/BF02190550

Key words

  • Atrialreflex
  • cardiacreceptors
  • autonomicnervous system
  • heartrate