Delta-9-tetrahydrocannabinol shows antispastic and analgesic effects in a single case double-blind trial

Summary

A double-blind study was performed comparing 5 mg delta-9-tetrahydrocannabinol (THC) p.o., 50 mg codeine p.o., and placebo in a patient with spasticity and pain due to spinal cord injury. The three conditions were applied 18 times each in a randomized and balanced order. Delta-9-THC and codeine both had an analgesic effect in comparison with placebo. Only delta-9-THC showed a significant beneficial effect on spasticity. In the dosage of THC used no altered consciousness occurred.

This is a preview of subscription content, access via your institution.

References

  1. Bellak L, Chassan JB (1964) An approach to the evaluation of drug effect during psychotherapy: a double-blind study of a single case. J Nerv Ment Dis 139:20–30

    Google Scholar 

  2. Chapsan JB (1960) Statistical inference and the single case in clinical design. Psychiatry 23:173–184

    Google Scholar 

  3. Cohen J (1977) Statistical power analysis for the behavioral sciences. Academic Press, London

    Google Scholar 

  4. Dittrich A (1985) Aetiologie-unabhängige Strukturen veränderter Wachbewusstseinzustände. Ergebnisse empirischer Untersuchungen über Halluzinogene I. und II. Ordnung, sensorische Deprivation, hypnagoge Zustände, hypnotische Verfahren sowie Reizüberflutung. Enke, Stuttgart

    Google Scholar 

  5. Dunn M, Davis R (1974) The perceived effects of marijuana on spinal cord injured males. Paraplegia 12:175

    Google Scholar 

  6. Fahrenberg J, Hampel R, Selg H (1984) Das Freiburger Persönlichkeitsinventar FPI, 4th edn. Hogrefe, Zürich

    Google Scholar 

  7. Malec J, Harvey RF, Cayner JJ (1982) Cannabis effect on spasticity in spinal cord injury. Arch Phys Med Rehabil 63:116–118

    Google Scholar 

  8. Mechoulam R (ed) (1986) Cannabinoids as therapeutic agents. CRC Press, Boca Raton

    Google Scholar 

  9. Meinck H-M, Schönle PW, Conrad B (1989) Effect of cannabinoids on spasticity and ataxia in multiple sclerosis. J Neurol 236:120–122

    Google Scholar 

  10. Noyes RN Jr, Brunk SF, Avery DH, Canter A (1975) The analgesic properties of delta-9-tetrahydrocannabinol. Clin Pharmacol Ther 18:84

    Google Scholar 

  11. O'Shaughnessy R (1842) On the preparation of the indian hemp or gunjah (cannabis indica): the effects on the animal system in health and their utility in the treatment of tetanus and other convulsive diseases. Trans Med Physiol Soc Bombay 8:421

    Google Scholar 

  12. Petro JP (1980) Marihuana as a therapeutic agent for muscle spasm or spasticity. Psychosomatics 21:81–85

    Google Scholar 

  13. Petro JP, Ellenberger C (1981) Treatment of human spasticity with delta-9-tetrahydrocannabinol. J Clin Pharmacol 21:413–416

    Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to V. Henn.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Maurer, M., Henn, V., Dittrich, A. et al. Delta-9-tetrahydrocannabinol shows antispastic and analgesic effects in a single case double-blind trial. Eur Arch Psychiatry Clin Nuerosci 240, 1–4 (1990). https://doi.org/10.1007/BF02190083

Download citation

Key words

  • Delta-9-tetrahydrocannabinol
  • Analgesia
  • Spasticity
  • Spinal cord injury