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Delta-9-tetrahydrocannabinol shows antispastic and analgesic effects in a single case double-blind trial

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A double-blind study was performed comparing 5 mg delta-9-tetrahydrocannabinol (THC) p.o., 50 mg codeine p.o., and placebo in a patient with spasticity and pain due to spinal cord injury. The three conditions were applied 18 times each in a randomized and balanced order. Delta-9-THC and codeine both had an analgesic effect in comparison with placebo. Only delta-9-THC showed a significant beneficial effect on spasticity. In the dosage of THC used no altered consciousness occurred.

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  • Bellak L, Chassan JB (1964) An approach to the evaluation of drug effect during psychotherapy: a double-blind study of a single case. J Nerv Ment Dis 139:20–30

    Google Scholar 

  • Chapsan JB (1960) Statistical inference and the single case in clinical design. Psychiatry 23:173–184

    Google Scholar 

  • Cohen J (1977) Statistical power analysis for the behavioral sciences. Academic Press, London

    Google Scholar 

  • Dittrich A (1985) Aetiologie-unabhängige Strukturen veränderter Wachbewusstseinzustände. Ergebnisse empirischer Untersuchungen über Halluzinogene I. und II. Ordnung, sensorische Deprivation, hypnagoge Zustände, hypnotische Verfahren sowie Reizüberflutung. Enke, Stuttgart

    Google Scholar 

  • Dunn M, Davis R (1974) The perceived effects of marijuana on spinal cord injured males. Paraplegia 12:175

    Google Scholar 

  • Fahrenberg J, Hampel R, Selg H (1984) Das Freiburger Persönlichkeitsinventar FPI, 4th edn. Hogrefe, Zürich

    Google Scholar 

  • Malec J, Harvey RF, Cayner JJ (1982) Cannabis effect on spasticity in spinal cord injury. Arch Phys Med Rehabil 63:116–118

    Google Scholar 

  • Mechoulam R (ed) (1986) Cannabinoids as therapeutic agents. CRC Press, Boca Raton

    Google Scholar 

  • Meinck H-M, Schönle PW, Conrad B (1989) Effect of cannabinoids on spasticity and ataxia in multiple sclerosis. J Neurol 236:120–122

    Google Scholar 

  • Noyes RN Jr, Brunk SF, Avery DH, Canter A (1975) The analgesic properties of delta-9-tetrahydrocannabinol. Clin Pharmacol Ther 18:84

    Google Scholar 

  • O'Shaughnessy R (1842) On the preparation of the indian hemp or gunjah (cannabis indica): the effects on the animal system in health and their utility in the treatment of tetanus and other convulsive diseases. Trans Med Physiol Soc Bombay 8:421

    Google Scholar 

  • Petro JP (1980) Marihuana as a therapeutic agent for muscle spasm or spasticity. Psychosomatics 21:81–85

    Google Scholar 

  • Petro JP, Ellenberger C (1981) Treatment of human spasticity with delta-9-tetrahydrocannabinol. J Clin Pharmacol 21:413–416

    Google Scholar 

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Maurer, M., Henn, V., Dittrich, A. et al. Delta-9-tetrahydrocannabinol shows antispastic and analgesic effects in a single case double-blind trial. Eur Arch Psychiatry Clin Nuerosci 240, 1–4 (1990).

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