Delta-9-tetrahydrocannabinol shows antispastic and analgesic effects in a single case double-blind trial

  • M. Maurer
  • V. Henn
  • A. Dittrich
  • A. Hofmann
Original Articles

Summary

A double-blind study was performed comparing 5 mg delta-9-tetrahydrocannabinol (THC) p.o., 50 mg codeine p.o., and placebo in a patient with spasticity and pain due to spinal cord injury. The three conditions were applied 18 times each in a randomized and balanced order. Delta-9-THC and codeine both had an analgesic effect in comparison with placebo. Only delta-9-THC showed a significant beneficial effect on spasticity. In the dosage of THC used no altered consciousness occurred.

Key words

Delta-9-tetrahydrocannabinol Analgesia Spasticity Spinal cord injury 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Bellak L, Chassan JB (1964) An approach to the evaluation of drug effect during psychotherapy: a double-blind study of a single case. J Nerv Ment Dis 139:20–30Google Scholar
  2. Chapsan JB (1960) Statistical inference and the single case in clinical design. Psychiatry 23:173–184Google Scholar
  3. Cohen J (1977) Statistical power analysis for the behavioral sciences. Academic Press, LondonGoogle Scholar
  4. Dittrich A (1985) Aetiologie-unabhängige Strukturen veränderter Wachbewusstseinzustände. Ergebnisse empirischer Untersuchungen über Halluzinogene I. und II. Ordnung, sensorische Deprivation, hypnagoge Zustände, hypnotische Verfahren sowie Reizüberflutung. Enke, StuttgartGoogle Scholar
  5. Dunn M, Davis R (1974) The perceived effects of marijuana on spinal cord injured males. Paraplegia 12:175Google Scholar
  6. Fahrenberg J, Hampel R, Selg H (1984) Das Freiburger Persönlichkeitsinventar FPI, 4th edn. Hogrefe, ZürichGoogle Scholar
  7. Malec J, Harvey RF, Cayner JJ (1982) Cannabis effect on spasticity in spinal cord injury. Arch Phys Med Rehabil 63:116–118Google Scholar
  8. Mechoulam R (ed) (1986) Cannabinoids as therapeutic agents. CRC Press, Boca RatonGoogle Scholar
  9. Meinck H-M, Schönle PW, Conrad B (1989) Effect of cannabinoids on spasticity and ataxia in multiple sclerosis. J Neurol 236:120–122Google Scholar
  10. Noyes RN Jr, Brunk SF, Avery DH, Canter A (1975) The analgesic properties of delta-9-tetrahydrocannabinol. Clin Pharmacol Ther 18:84Google Scholar
  11. O'Shaughnessy R (1842) On the preparation of the indian hemp or gunjah (cannabis indica): the effects on the animal system in health and their utility in the treatment of tetanus and other convulsive diseases. Trans Med Physiol Soc Bombay 8:421Google Scholar
  12. Petro JP (1980) Marihuana as a therapeutic agent for muscle spasm or spasticity. Psychosomatics 21:81–85Google Scholar
  13. Petro JP, Ellenberger C (1981) Treatment of human spasticity with delta-9-tetrahydrocannabinol. J Clin Pharmacol 21:413–416Google Scholar

Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • M. Maurer
    • 1
  • V. Henn
    • 2
  • A. Dittrich
    • 1
  • A. Hofmann
    • 3
  1. 1.PSIN-Psychologisches Institut für Beratung und ForschungZürichSwitzerland
  2. 2.Neurologische Klinik und Poliklinik der Universität ZürichZürichSwitzerland
  3. 3.Pharmakologisches Institut der Universität ZürichZürichSwitzerland

Personalised recommendations