Delta-9-tetrahydrocannabinol shows antispastic and analgesic effects in a single case double-blind trial

  • M. Maurer
  • V. Henn
  • A. Dittrich
  • A. Hofmann
Original Articles


A double-blind study was performed comparing 5 mg delta-9-tetrahydrocannabinol (THC) p.o., 50 mg codeine p.o., and placebo in a patient with spasticity and pain due to spinal cord injury. The three conditions were applied 18 times each in a randomized and balanced order. Delta-9-THC and codeine both had an analgesic effect in comparison with placebo. Only delta-9-THC showed a significant beneficial effect on spasticity. In the dosage of THC used no altered consciousness occurred.

Key words

Delta-9-tetrahydrocannabinol Analgesia Spasticity Spinal cord injury 


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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • M. Maurer
    • 1
  • V. Henn
    • 2
  • A. Dittrich
    • 1
  • A. Hofmann
    • 3
  1. 1.PSIN-Psychologisches Institut für Beratung und ForschungZürichSwitzerland
  2. 2.Neurologische Klinik und Poliklinik der Universität ZürichZürichSwitzerland
  3. 3.Pharmakologisches Institut der Universität ZürichZürichSwitzerland

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