Summary
The authors examined the dose response relationship between plasma ACTH and cortisol concentrations after the administration of various doses of ACTH1–24 (0.025 μg, 0.125 μg, 0.25 μg, 1 μg, 250 μg) in dexamethasone-suppressed normal volunteers. A logarithmic dose-response relationship between the dose of ACTH administered and plasma cortisol concentration was found. Although there was considerable variability in plasma ACTH concentrations, there was, however, a definite correlation between area under the curve for ACTH and area under the curve for cortisol after the various doses of ACTH.
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References
Fehm HL, Holl R, Klein E, Voigt KH (1984a) Evidence for ACTH unrelated mechanisms in the regulation of cortisol secretion in man. Klin Wochenschr 62:19–24
Fehm HL, Klein E, Holl R, Voigt KH (1984b) Evidence for extrapituitary mechanisms mediating the morning peak of plasma cortisol in man. J Clin Endocrinol Metab 58:410–414
Hollander M, Wolfe DA (1973) Nonparametric statistical methods. Wiley, New York, pp 147–150
Kolanowski J, Pizarro MA, Crabbe JK (1975) Potentiation of adrenocortical response upon intermittent stimulation with corticotropin in normal subjects. J Clin Endocrinol Metab 41: 453–463
Krieger DT, Allen W (1975) Relationship of bioassayable and immunoassayable plasma ACTH and cortisol concentration in normal subjects and in patients with Cushing' syndrome. J Clin Endocrinol Metab 10:675–687
Krishnan KRR, Manepalli AN, Ritchie JC, Venkatraman S, France R, Nemeroff CB, Carroll BJ (1988a) What is the relationship between plasma ACTH and plasma cortisol in normal humans and depressed patients? In: Schatzberg AF, Nemeroff CB (eds) HPA axis: physiology. Pathophysiology and psychiatric implications. Raven Press, New York, pp 105–108
Krishnan KRR, Ritchie JC, Manepalli AN, Nemeroff CB, Carroll BJ (1988b) Adrenocortical sensitivity to ACTH in humans. Biol Psychol 24:105–108
Landon J, James HT, Wharton MJ, et al (1967) Threshold adrenocortical sensitivity in man and its possible application to corticotropin bioassay. Lancet ii:697–700
LeClerq R, Copinschi G, Bruno OD (1972) Adrenocortical responsiveness to physiologic amounts of ACTH 1-24. Effects of prior administration of dexamethasone. Horm Metab Res 4: 202–206
Ritchie JC, Belkin BM, Krishnan KRR, Nemeroff CB, Carroll BJ (1989) Plasma dexamethasone concentrations and the dexamethasone suppression test. Biol Psychol 27:159–173
Wood CE, Shinsako J, Keil LC, Dallman MF (1982) Apparent dissociation of adrenocorticotropin and corticosteroid responses to 15 ml/kg hemorrhage in conscious dogs. Endocrinology 110: 1416–1421
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Krishnan, K.R.R., Miller, M.N., Helms, M.J. et al. Dose response relationship between plasma ACTH and cortisol after the infusion of ACTH1–24 . Eur Arch Psychiatry Clin Nuerosci 242, 240–243 (1993). https://doi.org/10.1007/BF02189969
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DOI: https://doi.org/10.1007/BF02189969