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Nocturnal sleep and oxygen balance in Duchenne muscular dystrophy

A clinicla and polygraphic 2-year follow-up study
  • Raffaele Manni
  • Claudio Zucca
  • Carlo Andrea Galimberti
  • Alberto ottolini
  • Isa Cerveri
  • Claudio Bruschi
  • Maria Cristina Zoia
  • Giovanni Lanzi
  • Amelia Tartara
Original Articles

Summary

A long-term, clinical and polygraphic investigation of nocturnal sleep was performed in nine non-ambulatory Duchenne muscular dystrophy patients (mean age 16.2 years, range 10–20) with normal daytime blood gas tensions. The data show that nocturnal sleep has some adverse influence on oxygen balance in these patients as suggested by the occurrence of arterial oxyhaemoglobin desaturation occurring mainly during REM stages. This adverse effect tended to worsen significantly within a 2-year period in the absence of any sleep-related symptoms. A significant correlation between the degree of oxygen imbalance during sleep and the degree of restrictive thoratic syndrome during wakefulness was shown.

Key words

Sleep Respiration Duchenne muscular dystrophy 

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Copyright information

© Springer-Verlag 1991

Authors and Affiliations

  • Raffaele Manni
    • 1
  • Claudio Zucca
    • 1
  • Carlo Andrea Galimberti
    • 1
  • Alberto ottolini
    • 2
  • Isa Cerveri
    • 3
  • Claudio Bruschi
    • 3
  • Maria Cristina Zoia
    • 3
  • Giovanni Lanzi
    • 2
  • Amelia Tartara
    • 1
  1. 1.Neurologic Clinic, Institute of Neurology “C. Mondino”University of PaviaPaviaItaly
  2. 2.Division of Child Neurology, Institute of Neurology “C. Mondino”University of PaviaPaviaItaly
  3. 3.Institute of Respiratory DiseaseUniversity of PaviaPaviaItaly

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