A search for association between schizophrenia and dopamine-related alleles

  • E. Jönsson
  • S. Brené
  • Th. Geijer
  • L. Terenius
  • A. Tylec
  • M. -L. Persson
  • G. Sedvall
Original Paper


Dopamine receptor dysfunction and altered tyrosine hydroxylase activity have both been implicated in the pathophysiology of schizophrenia. Schizophrenic pationts and control subjects were examined for allele frequencies in the tyrosine hydroxylase and dopamine D2 and D4 receptor genes. No significant differences of allele or genotype frequencies were found between the two groups after adjustment for multiple comparison. Neither were any significant relationships observed between allele frequencies and a number of clinical variables within the schizoprenic subsample. When no adjustment was made for multiple testing a few significant tendencies were obtained which warrant further research in extended patient and control materials. The results are compatible with the view that the tyrosine hydroxylase, dopamine receptor D2 and D4 gene polymorphisms examined are not of major importance in the aetiology or pathophysiology of schizophrenia.

Key words

Schizophrenia Association study Dopamine receptors (DRD2, DRD4) Tyrosine hydroxylase 


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Copyright information

© Springer-Verlag 1996

Authors and Affiliations

  • E. Jönsson
    • 1
  • S. Brené
    • 1
  • Th. Geijer
    • 1
  • L. Terenius
    • 1
  • A. Tylec
    • 1
  • M. -L. Persson
    • 2
    • 3
  • G. Sedvall
    • 1
  1. 1.Department of Clinical NeuroscienceKarolinska InstituteStockholmSweden
  2. 2.Department of Clinical Neuroscience and Family Medicine, Section of PsychiatryKarolinska InstituteStockholmSweden
  3. 3.National Institute for Psychosocial Factors and Health, Karolinska InstituteNational and Stockholm County Council Centre for Suicide Research and PreventionStockholmSweden

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